Center of Molecular Medicine
Publications: Complete collection
The list below is a joint list of all publications of the Division of Molecular Medicine (from 2002). To consult the list with only recent publications of the Laboratory of Molecular Virology and Genetherapy click here. To consult the list with only recent publications affiliated by the Laboratory of Neurobiology and Genetherapy click here.
| 2011 | 2010*° | 2009*° | 2008*° |
| 2007*° | 2006*° | 2005*° | 2004*° |
| 2003*° | 2002*° | ||
* with links to Pubmed abstract: [Pubmed link]
° with links to pdf-file of full article: [pdf]
Due to copyrights pdf's are only accessible for group members. But according to your institution's e-registration, most articles are available through PubMed. Not available: request for article: please MAIL
Yearly International Publication list (2002-2011)
(in reviewed Journals)
2012
Evens N, Vandeputte C, Coolen C, Janssen P, Sciot R, Baekelandt V, Verbruggen AM, Debyser Z, Van Laere K, Bormans GM. Preclinical evaluation of [(11)C]NE40, a type 2 cannabinoid receptor PET tracer. Nucl Med Biol. 2011 Dec 9. [Epub ahead of print] [Pubmed] [pdf]
Basu A, Drame A, Muñoz R, Gijsbers R, Debyser Z, De Leon M, Casiano CA. Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. Prostate. 2011 Jul 27. doi: 10.1002/pros.21463. [Epub ahead of print] [Pubmed] [pdf]
Reekmans K, Praet J, Daans J, Reumers V, Pauwels P, Van der Linden A, Berneman ZN, Ponsaerts P. Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research. Stem Cell Rev. 2011 May 3. [Epub ahead of print] [Pubmed] [no pdf]
Verhaar R, Jongenelen CA, Gerard M, Baekelandt V, Van Dam AM, Wilhelmus MM, Drukarch B. Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease. Neurochem Int. 2011 Mar 31. [Epub ahead of print] [Pubmed] [pdf]
Desimmie BA, Schrijvers R, Debyser Z. Elvitegravir: a once daily alternative to raltegravir. Lancet Infect Dis. 12(1):3-5. [no abstract] [Pubmed] [pdf]
2011
Oliveras-Salvá M, Van Rompuy A-S, Heeman B, Van den Haute C, Baekelandt V. Loss-of-Function Rodent Models for Parkin and PINK1. J Parkinson's Disease 1 (3):229-251. [abstract] [pdf]
Gijsbers R, Vets S, De Rijck J, Ocwieja K, Ronen K, Malani N, Bushman FD, Debyser Z. Role Of The PWWP Domain Of LEDGF/P75 In Lentiviral Integration Targeting. J Biol Chem. 286(48):41812-25. [Pubmed] [pdf]Taymans JM, Vancraenenbroeck R, Ollikainen P, Beilina A, Lobbestael E, De Maeyer M, Baekelandt V, Cookson MR. LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding. PLoS One. 2011;6(8):e23207. [Pubmed] [pdf]
Vancraenenbroeck R, Lobbestael E, De Maeyer M, Baekelandt V, Taymans JM. Kinases as Targets for Parkinson's Disease: from Genetics to Therapy. CNS Neurol Disord Drug Targets. 2011 Aug 15. [Epub ahead of print] [Pubmed] [pdf]
Varcin M, Bentea E, Mertens B, Van Den Haute C, Baekelandt V, Michotte Y, Sarre S. Acute versus long-term effects of 6-hydroxydopamine on oxidative stress and dopamine depletion in the striatum of mice. J Neurosci Methods. 2011 Jul 18. [Epub ahead of print] [Pubmed] [pdf]
Basu A, Drame A, Muñoz R, Gijsbers R, Debyser Z, De Leon M, Casiano CA. Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. Prostate. 2011 Jul 27. doi: 10.1002/pros.21463. [Epub ahead of print] [Pubmed] [pdf]
De Luca L, Gitto R, Christ F, Ferro S, De Grazia S, Morreale F, Debyser Z, Chimirri A. 4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process. Antiviral Res. 2011 Jul 15. [Epub ahead of print] [Pubmed] [pdf]
Madlala P, Gijsbers R, Christ F, Hombrouck A, Werner L, Mlisana K, An P, Karim SS, Winkler CA, Debyser Z, Ndungʼu T. Association of Polymorphisms in the LEDGF/p75 Gene (PSIP1) with Susceptibility to HIV-1 Infection and Disease Progression. AIDS. 2011 Jun 15. [Epub ahead of print] No abstract available.
Verhaar R, Jongenelen CA, Gerard M, Baekelandt V, Van Dam AM, Wilhelmus MM, Drukarch B. Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease. Neurochem Int. 2011 Mar 31. [Epub ahead of print] [Pubmed] [pdf]
Reekmans KP, Praet J, De Vocht N, Tambuyzer BR, Bergwerf I, Daans J, Baekelandt V, Vanhoutte G, Goossens H, Jorens PG, Ysebaert DK, Chatterjee S, Pauwels P, Van Marck E, Berneman ZN, Van der Linden A, Ponsaerts P. Clinical potential of intravenous neural stem cell delivery for treatment of neuro-inflammatory disease in mice? Cell Transplant. 2010 Nov 19. [Epub ahead of print] [Pubmed] [pdf]
Schrijvers R, Desimmie BA, Debyser Z. Rilpivirine: a step forward in tailored HIV treatment. Lancet. 2011 Jul 16;378(9787):201-3. [Pubmed] [pdf]
Deleersnijder A, Van Rompuy AS, Desender L, Pottel H, Buee L, Debyser Z, Baekelandt V, Gerard M. Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of {alpha}-synuclein aggregation. J Biol Chem. 286(30):26687-701. [Pubmed] [pdf]
Gerard M, Deleersnijder A, Demeulemeester J, Debyser Z, Baekelandt V. Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration. Mol Neurobiol. 44(1):13-27. [Pubmed] [pdf]
McNeely M, Hendrix J, Busschots K, Boons E, Deleersnijder A, Gerard M, Christ F, Debyser Z. In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75. J Mol Biol. 410(5):811-30. [Pubmed] [pdf]
Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M. Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation. ChemMedChem. 6(8):1371-89. [Pubmed] [pdf]
Ferro S, Grazia SD, De Luca L, Gitto R, Faliti CE, Debyzer Z, Chimirri A. Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors. Molecules16(8): 6858-6870. [Pubmed] [pdf]
Evens N, Vandeputte C, Muccioli GG, Lambert DM, Baekelandt V, Verbruggen AM, Debyser Z, Van Laere K, Bormans GM. Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. Bioorg Med Chem. 19(15):4499-505. [Pubmed] [pdf]
Vandeputte C, Evens N, Toelen J, DerooseCM, Bosier B, Ibrahimi A, Van der Perren A, Gijsbers R, Janssen P, Lambert DM, Verbruggen A, Debyser Z, Bormans G, Baekelandt V, Van Laere K. A PET Brain Reporter Gene System Based on Type 2 Cannabinoid Receptors. J. Nucl. Med. 52(7):1102-9. [Pubmed] [pdf]
Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M. miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol. 2011 193(7):1197-212. [Pubmed] [pdf]
Daniëls V, Baekelandt V, Taymans J-M. On the road to LRRK2 signalling: evidence from cellular and in vivo studies. NeuroSignals, 19(1):1-15. [Pubmed] [pdf]
Heeman B, Van Den Haute C, Aelvoet S-A,Valsecchi F, Rodenburg R, Reumers V, Debyser Z, Callewaert G, Koopman W, Willems P, Baekelandt V. Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci. 124(7):1115-1125. [Pubmed] [pdf]
Vande Velde G, Rangarajan JR, Toelen J, Dresselaers T, Ibrahimi A, Krylychkina O, Vreys R, Van der Linden A, Maes F, Debyser Z, Himmelreich U, Baekelandt V. The specificity and sensitivity of ferritin as an MRI reporter gene in mouse brain using lentiviral and adeno-associated viral vectors. Gene Therapy 18(6):594-605. [Pubmed] [pdf]
Van der Perren A, Toelen J, Carlon M, Van Den Haute C, Coun F, Heeman B, Reumers V, Vandenberghe LH, Wilson JM, Debyser Z, Baekelandt V. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene Therapy 18(5):517-27. [Pubmed] [pdf]
Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM. Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. J Neurochem. 116(2):304-15. [Pubmed] [pdf]
Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J-i, McNeely M, Hofkens J, Debyser Z, Engelborghs Y. The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic Acid Research 39(4):1310-1325. [Pubmed] [pdf]
Thys W, De Houwer S, Demeulemeester J, Taltynov O, Vancraenenbroeck R, Gérard M, De Rijck J, Gijsbers R, Christ F, Debyser Z. Interplay between HIV entry and transportin-SR2 dependency. Retrovirology 8(1):7. [Pubmed] [pdf]
Vandeputte C, Thomas D, Dresselaers T, Crabbe A, Verfaillie C, Baekelandt V, Van Laere K, Himmelreich U. Characterization of the Inflammatory Response in a Photothrombotic Stroke Model by MRI: Implications for Stem Cell Transplantation. Molecular Imaging & Biology 13(4):663-71. [Pubmed] [pdf]
Billamboz M, Bailly F, Lion C, Touati N, Vezin H, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function. J Med Chem. 54(6):1812-24. [Pubmed] [pdf]
Billamboz M, Bailly F, Lion C, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, De Luca L, Chimirri A, Cotelle P. 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4. Eur J Med Chem. 46(2):535-546. [Pubmed] [pdf]
De Luca L, De Grazia S, Ferro S, Gitto R, Christ F, Debyser Z, Chimirri A. HIV-1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation. Eur J Med Chem. 46 (2): 756-764. [Pubmed] [pdf]
Rinaldi M, Tintori C, Franchi L, Vignaroli G, Innitzer A, Massa S, Esté JA, Gonzalo E, Christ F, Debyser Z, Botta M. A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors. ChemMedChem 6(2):343-52. [Pubmed] [pdf]
2010
Carlon M, Toelen J, Van der Perren A, Vandenberghe LH, Reumers V, Sbragia L, Gijsbers R, Baekelandt V, Himmelreich U, Wilson JM, Deprest J, Debyser Z. Efficient gene transfer into the mouse lung by fetal intratracheal injection of AAV2/6.2. Mol. Therapy 18(12):2130-8. [Pubmed link] [pdf]
De Rijck J, Bartholomeeusen K, Ceulemans H, Debyser Z, Gijsbers R. High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. Nucleic Acids Research 38(18):6135-47. [Pubmed link] [pdf].
Vandeputte C, Taymans JM, Casteels C, Coun F, Ni Y, Van Laere K, Baekelandt V. Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience 11 (1):92. [Pubmed] [pdf]
Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z. Rational design of first-in-class inhibitors of LEDGF/p75-integrase interaction and HIV replication. Nature Chemical Biology 6(6):442-8. [Pubmed link] [pdf] [supplement]
Taymans JM, Cookson MR. Mechanism in dominant parkinsonism: the toxic triangle of LRRK2, alpha-synuclein, and tau. BioEssays 32(3):227-35. [Pubmed link] [pdf]
Gérard M, Deleersnijder A, Daniëls V, Schreurs S, Munck S, Reumers V, Pottel H, Engelborghs Y, Van Den Haute C, Taymans JM, Debyser Z, Baekelandt V. Inhibition of FK506 Binding Proteins reduces alpha-synuclein aggregation and Parkinson’s disease-like pathology. J Neurosci. 30(7):2454-2463. [Pubmed link] [pdf]
Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman F, Debyser Z. LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Molecular Therapy 18(3): 552-560. [Pubmed link] [pdf]
Lobbestael E, Reumers V, Ibrahimi A, Paesen K, Thiry I, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V, Taymans JM. Immunohistochemical detection of transgene expression in the brain using small epitope tags. BMC Biotechnol. 10(1):16. [Pubmed] [pdf]
Meuvis J, Gerard M, Desender L, Baekelandt V, Engelborghs Y. The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region. Biochemistry. 49(43):9345-52. [Pubmed link] [pdf]
De Luca L, Ferro S, Gitto R, Barreca ML, Agnello S, Christ F, Debyser Z, Chimirri A. Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. Bioorg Med Chem. 18(21):7515-21 [Pubmed] [pdf]
Casteels C, Martinez E, Bormans G, Camon L, de Vera N, Baekelandt V, Planas A, Van Laere K. Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism. European Journal of Nuclear Medicine and Molecular Imaging 37(12):2354-63. [Pubmed] [pdf]
Lock M, Alvira M, Vandenberghe LH, Samanta A, Toelen J, Debyser Z, Wilson JM. Rapid, Simple and Versatile Manufacturing of Recombinant Adeno-Associated Virus Vectors at Scale. Hum Gene Ther. 21(10):1259-71. [Pubmed link] [pdf]
Maurin C, Lion C, Bailly F, Touati N, Vezin H, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase-Discovery of a new polyhydroxylated antiviral agent. Bioorg Med Chem.18(14):5194-201. [Pubmed link] [pdf]
Ferro S, De Luca L, Barreca ML, De Grazia S, Christ F, Debyser Z, Chimirri Alba. New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. Bioorg med chem 18(15):5510-8. [Pubmed] [pdf]
Van Camp N, Vreys R, Van Laere K, Lauwers E, Beque D, Verhoye M, Casteels C, Verbruggen A, Debyser Z, Mortelmans L, Sijbers J, Nuyts J, Baekelandt V, Van der Linden, A. Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with µSPECT and quantitative MRI. MAGMA. 23(2):65-75. [Pubmed] [pdf]
Slaets H, Hendriks JJ, Van den Haute C, Coun F, Baekelandt V, Stinissen P, Hellings N. CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis.Mol Ther. 18(4):684-91. [Pubmed link] [pdf]
Coremans V, Ahmed T, Balschun D, D'Hooge R, De Vriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch A, Lagace D, Janssens T, Bozzi Y, Caleo M, Conway EM. Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neurosci. 11(1):2. [Pubmed link] [pdf]
Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans J, Wolozin B, Cookson MR. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One 5(1):e8730. [Pumed link] [pdf]
Fiesel FC, Voigt A, Weber SS, Van den Haute C, Waldenmaier A, Görner K, Walter M, Anderson ML, Kern JV, Rasse TM, Schmidt T, Springer W, Kirchner R, Bonin M, Neumann M, Baekelandt V, Alunni-Fabbroni M, Schulz JB, Kahle PJ. Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO Journal 29(1):209-21. [Pubmed link] [pdf]
Vreys R, Vande Velde G, Krylychkina O, Vellema M, Verhoye M, Timmermans JP, Baekelandt V, Van der Linden A. MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: Validation of various MPIO labeling strategies. NeuroImage 49(3):2094-2103. [Pubmed link] [pdf]
Dubois C, Liu X, Claus P, Marsboom G, Pokreisz P, Vandenwijngaert S, Dépelteau H, Streb W, Chaothawee L, Maes F, Gheysens O, Debyser Z, Gillijns H, Pellens M, Vandendriessche T, Chuah M, Collen D, Verbeken E, Belmans A, Van de Werf F, Bogaert J, Janssens S. Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction. J Am Coll Cardiol. 18;55(20):2232-43. [Pubmed link] [pdf]
Klaritsch P, Mayer S, Sbragia L, Toelen J, Roubliova X, Lewi P, Deprest J. Albumin as an adjunct to tracheal occlusion in fetal rats with congenital diaphragmatic hernia: a placebo-controlled study. Am J Obstet Gynecol. 202(2):198.e1-9. [Pubmed link] [pdf]
2009
Voet ARD, De Maeyer M, Debyser Z, Christ F. In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer. Future Med Chem 1(7):1259-1274. [Abstract] [No Pubmed link] [pdf]
Ferro S, Agnello S, Barreca ML, De Luca L, Christ F, Gitto R. Synthesis of New Pyridazine Derivatives as Potential Anti-HIV-1 Agents. J Heterocyclic Chem 46(6): 1420-1424.[Web of Science link] [pdf]
Pauwels K, Gijsbers R, Toelen J, Schambach A, Willard-Gallo K, Verheust C, Debyser Z, Herman P. State-of-the-art lentiviral vectors for research use: Risk assessment and biosafety recommendations. Current Gene Therapy. Curr Gene Ther. 9(6):459-74. [Pubmed link] [pdf]
Casteels C, Lauwers E, Baitar A, Bormans G, Baekelandt V, Van Laere K. In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease. Brain Res. 2009 Dec 21. [Epub ahead of print] [Pubmed link] [pdf]
Deprest JA, Devlieger R, Srisupundit K, Beck V, Sandaite I, Rusconi S, Claus F, Naulaers G, Van de Velde M, Brady P, Devriendt K, Vermeesch J, Toelen J, Carlon M, Debyser Z, De Catte L, Lewi L. Fetal surgery is a clinical reality. Semin Fetal Neonatal Med. 2009 Nov 11. [Epub ahead of print] [Pubmed link]
Vande Velde G, Baekelandt V, Dresselaers T, Himmelreich U. Magnetic resonance imaging and spectroscopy methods for molecular imaging. Q J Nucl Med Mol Imaging. 53(6):565-585. [Pubmed link] [pdf] [On some pages the text is covered by the water proof.]
Parisiadou L, Xie C, Lin X, Gu X, Long CX, Baekelandt V, Lobbestael E, Taymans JM, Sun L, Cai H. Phosphorylation of ERM Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis. J. Neurosci. 29(44):13971-80. [Pubmed link] [pdf]
Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR. The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochem Biophys Res Commun. 389(3):449-54. [Pubmed link] [pdf]
Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM.Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Ther.16(12):1416-28. [Pubmed link] [pdf]
Singh KB, Cavalluzzo C, De Maeyer M, Debyser Z, Parmar VS, Van der Eycken E. Microwave-Assisted Palladium-Catalyzed Heterogeneous Vinylation of 2(1H)-Pyridones. European Journal of Organic Chemistry 2009 (27): 4589-4592. [Web of Science] [pdf]
Singh KB, Cavalluzzo C, De Maeyer M, Debyser Z, Parmar VS, Van der Eycken E. Microwave-Assisted Silver(I)-Mediated Selective O-Alkylation of Aromatic Imidate Systems. Synthesis (Stuttgart) 16:2725-27289. [Web of Science] [no pdf]
Thys W, Busschots K, McNeely M, Voet A, Christ F, Debyser Z. LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy. HIV Ther. 2009, 3(2), 171–188. [no Pubmed link] [pdf]
Yang X, Mertens B, Lehtonen E, Vercammen L, Bockstael O, Chtarto A, Levivier M, Brotchi J, Michotte Y, Baekelandt V, Sarre S, Tenenbaum L. Reversible neurochemical changes mediated by delayed intrastriatal glial cell line-derived neurotrophic factor gene delivery in a partial Parkinson's disease rat model. J Gene Med. 11(10):899-912. [Pubmed link] [pdf]
De Luca L, Barreca ML, Ferro S, Christ F, Iraci N, Gitto R, Monforte AM, Debyser Z, Chimirri A. Pharmacophore-Based Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions between HIV-1 Integrase and Cellular Cofactor LEDGF/p75 ChemMedChem.4(8):1311-6. [Pubmed link] [pdf]
Celen S, Cleynhens J, Deroose C, de Groot T, Ibrahimi A, Gijsbers R, Debyser Z, Mortelmans L, Verbruggen A, Bormans G. Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging. Bioorg Med Chem. 17(14):5117-25. [Pubmed link] [pdf]
Rajamaki S, Innitzer A, Falciani C, Tintori C, Christ F, Witvrouw M, Debyser Z, Massa S, Botta M. Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. Bioorg Med Chem Lett.19(13):3615-8. [Pubmed link] [pdf]
Vermeire L, Ibrahimi A, Voet T, Umans L, Coddens K, Francis A, Van de Putte T, van Grunsven LA, Zwijsen A, Huylebroeck D, Nelles L. Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap. Int J Dev Biol. 53(7):1045-51. [Pubmed link] [pdf]
Deroose CM, Chitneni SK, Gijsbers R, Vermaelen P, Ibrahimi A, Verbruggen AV, Balzarini J, Baekelandt V, Nuyts J, Bormans GM, Debyser Z, Mortelmans L. Validation of varicella zoster virus thymidine kinase as a novel reporter gene for positron emission tomography, Under revision in European Journal of Nuclear Medicine and Molecular Imaging [No Pubmed link] [no pdf]
Ibrahimi A, Vande Velde G, Reumers V, Toelen J, Thiry I, Vandeputte C, Deroose C, Bormans G, Baekelandt V, Debyser Z,
Gijsbers R. Highly efficient multicistronic lentivectors with peptide 2A sequences. Hum Gene Ther. 20(8):845-60. [Pubmed link] [pdf HQ] [pdf fast download] [cover image] [about the cover]
Deroose CM, Reumers V, Debyser Z, Baekelandt V. Seeing genes at work in the living brain with non-invasive molecular imaging. Current Gene Therapy 9(3):212-38. [Pubmed link] [no pdf]
Van Camp N, Blockx I, Verhoye M, Casteels C, Coun F, Leemans A, Sijbers J, Baekelandt V, Van Laere K, Van der Linden A. Diffusion tensor imaging in a rat model of Parkinson’s disease after lesioning of the nigrostriatal tract. NMR Biomed. 22(7):697-706. [Pubmed link] [pdf]
Waak J, Weber SS, Waldenmaier A, Görner K, Alunni-Fabbroni M, Vogt-Weisenhorn D, Pham TT, Schütz M, Autenrieth IB, Reumers V, Baekelandt V, Wurst W, Kahle PJ. Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated Gene DJ-1. FASEB J. 23(8):2478-89. [Pubmed link] [pdf]
Bartholomeeusen K, Gijsbers R, Christ F, Hendrix J, Rain JC, Emiliani S, Benarous R, Debyser Z, De Rijck J.Lens Epithelium Derived Growth Factor/p75 interacts with the transposase derived DDE domain of pogZ. J Biol Chem. 284(17):11467-11477. [Pubmed link] [pdf]
Bergwerf I, De Vocht N, Tambuyzer B, Verschueren J, Reekmans K, Daans J, Ibrahimi A, Van Tendeloo V, Chatterjee S, Goossens H, Jorens P, Baekelandt V, Ysebaert D, Van Marck E, Berneman Z, Van der Linden A, Ponsaerts P. Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice. BMC Biotechnol. 9(1):1. [Pubmed link] [pdf]
Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 is a novel modulator of amyloid-beta peptide generation in neurons. Science, 323 (5916):946-51. [Pubmed link] [pdf]
Maes W, Deroose C, Reumers V, Krylyshkina O, Gijsbers R, Baekelandt V, Ceuppens J, Debyser Z, Van Gool SW. In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma. J Neurooncol. 91(2):127-39. [Pubmed link] [pdf]
Busschots K, De Rijck J, Christ F and Debyser Z. In search of small molecules blocking interactions between HIV proteins and intracellular cofactors. Mol. BioSyst. 5 (1): 21-31. [Pubmed link] [pdf]
Ferro S, De Luca L, Barreca ML, Iraci N, De Grazia S, Christ F, Witvrouw M, Debyser Z, Chimirri A. Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. J Med Chem. 52(2):569-73.
[Pubmed link] [pdf]
Ferro S, De Grazia S, De Luca L, Barreca ML, Debyser Z, Chimirri A. Structural modification of diketo acid portion in 1h-benzylindole derivatives hiv-1 integrase inhibitors. Heterocycles 78(4): 947-959. [Web of Science link] [pdf]
2008
Billamboz M, Bailly F, Barreca ML, De Luca L, Mouscadet JF, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, Cotelle P. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem. 51(24):7717-30. [Pubmed link] [pdf]
Greene WC, Debyser Z, Ikeda Y, Freed EO, Stephens E, Yonemoto W, Buckheit RW, Esté JA, Cihlar T. Novel targets for HIV therapy. Antiviral Res 80(3):251-65 . [Pubmed link] [pdf]
Pasquini Snext article, Mugnaini C, Tintori C, Botta M, Trejos A, Arvela RK, Larhed M, Witvrouw M, Michiels M, Christ F, Debyser Z, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem 51(16):5125-9. [Pubmed link] [no pdf]
Christ Fnext article, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z. Transportin-SR2 imports HIV into the nucleus. Curr Biol. 18(16):1192-202. [Pubmed link] [pdf] [Supplements]
Brown-Bryan TAnext article, Leoh LS, Ganapathy V, Pacheco FJ, Mediavilla-Varela M, Filippova M, Linkhart TA, Gijsbers R, Debyser Z, Casiano CA. Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Mol Cancer Res. 6(8):1293-307. [Pubmed link] [pdf]
Al-Mawsawi LQnext article, Hombrouck A, Dayam R, Debyser Z, Neamati N. Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity. Virology. 377(2):355-63. [Pubmed link] [pdf]
Reumers Vnext article, Deroose CM, Krylyshkina O, Nuyts J, Geraerts M, Mortelmans L, Gijsbers R, Van Den Haute C, Debyser Z, Baekelandt V. Non-invasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain using Bioluminescence Imaging. Stem Cells. 26(9):2382-2390.[Pubmed link] [pdf]
Plaas M, Karis A, Innos J, Rebane E, Baekelandt V, Vaarmann A, Luuk H, Vasar E, Koks S. Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. J Physiol Pharmacol. 59(2):205-16 [Pubmed link] [pdf]
Brandt Inext article, Gérard M, Sergeant K, Devreese B, Baekelandt V, Augustyns K, Scharpé S, Engelborghs Y, Lambeir AM. Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein. Peptides 29(9):1472-8. [Pubmed link] [pdf]
Greggio Enext article, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem 283(24):16906-14. [Pubmed link] [pdf]
Hombrouck Anext article, Van Remoortel B, Michiels M, Noppe W, Christ F, Eneroth A, Sahlberg BL, Benkestock K, Vrang L, Johansson NG, Barreca ML, De Luca L, Ferro S, Chimirri A, Debyser Z, Witvrouw M. Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Stran Transfer Inhibitors. Antimicrob Agents Chemother 2008 52(8)2861-1869. [Pubmed link] [pdf]
Hombrouck Anext article, Voet A, Van Remoortel B, Desadeleer C, De Maeyer M, Debyser Z, Witvrouw M. Mutations in HIV-1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross Resistance to the Clinical Trial drug GS-9137. Antimicrob Agents Chemother. 52(6):2069-78. [Pubmed link] [pdf]
Gerard Mnext article, Debyser Z, Desender L, Baert J, Brandt I, Baekelandt V, Engelborghs Y. FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. J Neurochem. 2008 106(1):121-33. [Pubmed link] [pdf]
Dubois Mnext article, Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. Reaction of Rosmarinic Acid with Nitrite Ions in Acidic Conditions: Discovery of Nitro- and Dinitrorosmarinic Acids as New Anti-HIV-1 Agents. J Med Chem 51(8):2575-9. [Pubmed link] [no pdf]
De Luca Lnext article, Barreca ML, Ferro S, Iraci N, Michiels M, Christ F, Debyser Z, Witvrouw M, Chimirri A. A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. Bioorg Med Chem Lett. 18(9):2891-5. [Pubmed link] [pdf]
Al-Mawsawi LQnext article, Christ F, Dayam R, Debyser Z, Neamati N. Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: Insight into integrase-DNA complex formation and catalysis. FEBS Lett. 582(10):1425-30. [Pubmed link] [pdf]
Dayam Rnext article, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem 51(5):1136-44. [Pubmed link] [no pdf]
Gielen Enext article, Smisdom N, De Clercq B, Vandeven M, Gijsbers R, Debyser Z, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M. Diffusion of Myelin Oligodendrocyte Glycoprotein in Living OLN-93 Cells Investigated by Raster-Scanning Image Correlation Spectroscopy (RICS). J Fluoresc. 18(5):813-9. [Pubmed link] [pdf]
Celen Snext article, Deroose C, de Groot T, Chitneni SK, Gijsbers R, Debyser Z, Mortelmans L, Verbruggen A, Bormans G. Synthesis and evaluation of 18F- and 11C-labelled phenyl-galactopyranosides as potential probes for in vivo visualization of lacZ gene expression using positron emission tomography. Bioconj. Chem. 19(2):441-9. [Pubmed link] [no pdf]
Chitneni SKnext article, Serdons K, Evens N, Fonge H, Celen S, Deroose CM, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. J Chromatogr A. 1189(1-2):323-31. [Pubmed link] [pdf]
Casteels Cnext article, Lauwers E, Bormans G, Baekelandt V, Van Laere K. Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model of Parkinson’s disease. Eur J Nucl Med Mol Imaging (1):124-34. [Pubmed link] [pdf]
Lin Ynext article, Liu X, Yan R, Li J, Pannecouque C, Witvrouw M, De Clercq E. Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs). Bioorg Med Chem. 16(1):157-63. [Pubmed link] [pdf]
Queffélec Cnext article, Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. Eur J Med Chem. 43(10):2268-71. [Pubmed link] [pdf]
Queffélec C, Bailly F, Mbemba G, Mouscadet JF, Hayes S, Debyser Z, Witvrouw M, Cotelle P. Synthesis and antiviral properties of some polyphenols related to Salvia genus. Bioorg Med Chem Lett. 18(16): 4736-4740. [Pubmed link] [pdf]
Selvam P, Murugesh N, Chandramoham M, Debyser Z, Witvrouw M. Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides. Indian journal of pharmaceutical sciences 70(9):779-782. [Abstract] [pdf]
2007
Toelen J, Gijsbers R, Sbragia L, Deroose C, Debyser Z, Deprest J. Long term pulmonary gene therapy with a lentiviral vector in a fetal rat model. Ultrasound Obstet Gynecol. 30(4):460. [pdf]
Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F. Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75. J Mol Bio 372(2):407-21. [Pubmed link] [pdf]
Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen S, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. A p-[(18)F]Fluoroethoxyphenyl Bicyclic Nucleoside Analogue as a Potential Positron Emission Tomography Imaging Agent for Varicella-Zoster Virus Thymidine Kinase Gene Expression. J Med Chem. 50(26):6627-37. [Pubmed link] [no pdf]
Al-Mawsawi LQ, Dayam R, Taheri L, Witvrouw M, Debyser Z, Neamati N. Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. Bioorg Med Lett 17(23):6472-6472. [Pubmed link] [pdf]
Wu J, Liu X, Cheng X, Cao Y, Wang D, Li Z, Xu W, Pannecouque C, Witvrouw M, De Clercq E. Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs. Molecules 12(8):2003-16. [Pubmed link] [pdf]
Maruyama T , Demizu Y, Kozai S, Witvrouw M, Pannecouque C, Balzarini J, Snoecks R, Andrei G, De Clercq E. Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV. Nucleosides Nucleotides Nucleic Acids 26 (10-12):1553-8. [Pubmed link] [no pdf]
Kronenberg G, Wang LP, Geraerts M, Babu H, Synowitz M, Vicens P, Lutsch G, Glass R, Yamaguchi M, Baekelandt V, Debyser Z, Kettenmann H, Kempermann G. Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1. Brain Struct Funct 212(1):19-35. [Pubmed link] [pdf]
Hombrouck A, Hantson A, Van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M (2007). Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action. J Antimicrob Chemother 59(6):1084-95. [Pubmed link] [pdf]
Mugnaini C, Rajamaki S, Tintori C, Corelli F, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies. Bioorg Med Chem Lett 17(19):5370-3. [Pubmed link] [pdf]
Tintori C, Manetti F, Veljkovic N, Perovic V, Vercammen J, Hayes S, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Novel Virtual screening protocol based on the combine use of molecular modelling and electron-ion intereaction potential techniques to design HIV-1 integrase inhibitors. J. Chem. Inf. Model. 2007: 47(4):1536-44. [Pubmed link] [no pdf]
Ferro S, Barreca ML, De Luca L, Rao A, Monforte AM, Debyser Z, Witvrouw M, Chimirri A. New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors. Arch Pharm (Weinheim) 340(6):292-8. [Pubmed link] [pdf]
De Rijck J, Vandekerckhove L, Christ F, Debyser Z. Lentiviral nuclear import: a complex interplay between virus and host. Bioessays. 29(5):441-51. [Pubmed link] [pdf]
Chitneni SK, Deroose CM, Fonge H, Gijsbers R, Dyubankova N, Balzarini J, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of an (123)I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett.17(12):3458-62. [Pubmed link] [pdf]
Toelen J, Deroose CM, Gijsbers R, Reumers V, Sbragia LN, Vets S, Chitnei SK, Bormans G, Mortelmans L, Deprest JA, Debyser Z. Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. Am J Obstet Gynecol 196(4):352.e1-6. [Pubmed link] [pdf]
Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z (2007). Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV. PLoS Pathog 3(3): e47. [Pubmed link] [free full text]
Taymans JM, Vandenberghe LH, Van den Haute C, Thiry I, Deroose CM, Mortelmans L, Wilson JM, Debyser Z, Baekelandt V. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther 18(3):195-206. [Pubmed link] [pdf]
Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen SJ, de Groot TJ, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 50(5):1041-9. [Pubmed link] [pdf]
Veljkovic V, Mouscadet JF, Veljkovic N, Glisic S, Debyser Z. Simple criterion for selection of flavonoid compounds with anti-HIV activity. Bioorg Med Chem Lett 1;17(5):1226-32. [Pubmed link] [pdf]
Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F. Identification of the LEDGF/p75 binding site in HIV-1 integrase. J mol biol 365,1480-1492. [Pubmed link] [pdf]
Lauwers E, Beque D, Van Laere K, Nuyts J, Bormans G, Mortelmans L, Casteels C, Vercammen L, Bockstael O, Nuttin B, Debyser Z, Baekelandt V. Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging. 28:248-257. [Pubmed link] [pdf]
Geraerts M, Krylychkina O, Debyser Z, Baekelandt V. Concise Review: Therapeutic strategies for Parkinson's disease based on the modulation of adult neurogenesis. Stem Cells 25(2):263-270. [Pubmed link] [pdf]
2006
De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F, Debyser Z. Overexpression of the lens epithelium-derived growth factor/p75 Integrase Binding Domain Inhibits HIV Replication. J Virol. 80 (23): 11498-11506. [Pubmed link] [pdf]
Vandekerckhove L, De Rijck J, Christ F, Gijsbers R, Debyser Z. RNAi-based treatment of HIV/AIDS: Current status and perspectives. Drug Discovery Today: Therapeutic Strategies 3(2): 227-235. [Science Direct link] [pdf]
Casteels C, Vermaelen P, Nuyts J, Van Der Linden A, Baekelandt V, Mortelmans L, Bormans G, Van Laere K. Construction and evaluation of Multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. J Nucl Med. 47(11):1858-66. [Pubmed link] [pdf]
De Rijck J, Debyser Z. The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication. Biochem Biophys Res Commun. 2006;349(3):1100-10. [Pubmed link] [pdf]
Vercammen L, Van der Perren A, Vaudano E, Gijsbers R, Debyser Z, Van den Haute C, Baekelandt V (2006). Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease. Mol Ther. 14:5, 716-723. [Pubmed link] [pdf]
Geraerts M, Willems S, Baekelandt V, Debyser Z, Gijsbers R. Comparison of lentiviral vector titration methods. BMC Biotechnol. 2006 Jul 12;6:34. [Pubmed link] [pdf]
Deroose CM, Reumers V, Gijsbers R, Debyser Z, Bormans G, Mortelmans L, Baekelandt V. Noninvasive Monitoring of Long-Term Lentiviral Vector-Mediated Gene Expression in Rodent Brain with Bioluminescence Imaging. Mol Ther. 14(3):423-31. [Pubmed link] [pdf]
Vandenberghe LH, Wang L, Somanathan S, Zhi Y, Figueredo J, Calcedo R, Sanmiguel J, Desai RA, Chen CS, Johnston J, Grant RL, Gao G, Wilson JM. Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nature Medicine 12, 967 - 971. [Pubmed link] [pdf]
Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z. Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther. 2006 Jun;17(6):635-50. [Pubmed link] [pdf]
Al-Mawsawi LQ, Fikkert V, Dayam R, Witvrouw M, Burke TR Jr, Borchers CH, Neamati N. Discovery of a small-molecule HIV-1 integrase inhibitor-binding site. PNAS USA 2006. 27;103(26):10080-5. [Pubmed link] [pdf]
Taymans JM, Van den Haute C, Baekelandt V. Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem. 2006 Aug;98(3):951-61. [Pubmed link] [pdf]
Gerard M, Debyser Z, Desender L, Kahle PJ, Baert J, Baekelandt V, Engelborghs Y. The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB J. Mar;20(3):524-6. [Pubmed link] [pdf]
Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z. Cellular co-factors of HIV-1 integration. Trends Biochem Sci. 80(4):1886-96. [Pubmed link] [pdf]
Vandekerckhove L, Christ F, Van Maele B, De Rijck J, Gijsbers R, Van den Haute C, Witvrouw M, Debyser Z. Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol. 2006; 80(4):1886-96. [Pubmed link] [pdf]
Taymans JM, Kia HK, Langlois X. Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation. Neurosci Lett. 2006 Jan 2;391(3):116-21. [Pubmed link] [pdf]
Adams MM, Bats JW, Nikolaus NV, Witvrouw M, Debyser Z, Engels JW. Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase. Coll Czech Chem Comm 71 (7): 978-990, 2006. [abstract available on Web of Science] [pdf]
Maruyama T, Kozai S, Demizu Y, Witvrouw M, Pannecouque C, Balzarini J, Snoecks R, Andrei G, De Clercq E. Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives. Chem Pharm Bull (Tokyo). 2006 Mar;54(3):325-33. [Pubmed link] [pdf]
Yan RZ, Liu XY, Xu WF, Pannecouque C, Witvrouw M, De Clercq E. Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines. Arch Pharm Res. 29(11):957-62. [Pubmed link] [no-pdf]
2005
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. J Biol Chem. 2005 May 6;280(18):17841-7.[Pubmed link] [pdf]
De Rijck J, Van Maele B, Debyser Z. Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors. Biochem Biophys Res Commun. 2005 Mar 25;328(4):987-94. [Pubmed link] [pdf]
Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G , De Clercq E , Vandamme AM , Debyser Z , Witvrouw M . Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology. Antivir Chem Chemother. 2005;16(4):253-66. [Pubmed link] [pdf]
Geraerts M, Michiels M, Baekelandt V, Debyser Z, Gijsbers R. Upscaling of lentiviral vector production by tangential flow filtration. J Gene Med. 2005 Oct;7(10):1299-310. [Pubmed link] [pdf]
Maertens G, Vercammen J, Debyser Z, Engelborghs Y. Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75. FASEB J. 2005 Jun;19(8):1039-41. [Pubmed link] [pdf]
Taymans JM, Kia HK, Groenewegen HJ, Leysen JE, Langlois X. Bilateral control of brain activity by dopamine D1 receptors: evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats . Neuroscience. 2005;134(2):643-56. [Pubmed link] [pdf]
van Griensven J, De Clercq E, Debyser Z. Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. AIDS Rev. 2005 Jan-Mar;7(1):44-55. [Pubmed link] [pdf]
Van Maele B, Debyser Z. HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. AIDS Rev. 7(1):26-43. [Pubmed link] [pdf]
Van Maele B, Van Eylen L, Pluymers W, Debyser Z. Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells. Biochem Biophys Res Commun. 4;327(1):261-7. [Pubmed link] [pdf]
Witvrouw M, Fikkert V, Vercammen J, Van Maele B, Engelborghs Y, Debyzer Z (2005). Identification of Authentic Inhibitors of HIV integration. Curr. Med. Chem. Anti-infective agents, 4: 153-165. [no link to pubmed] [pdf]
Witvrouw M, Fikkert V, Hantson A, Pannecouque C, O'keefe BR, McMahon J, Stamatatos L, de Clercq E, Bolmstedt A. Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J Virol. 79(12):7777-84. [Pubmed link] [pdf]
Barreca ML, Ferro S, Rao A, De Luca L, Zappala M, Monforte AM, Debyser Z, Witvrouw M, Chimirri A. Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. J Med Chem. 2005 Nov 3;48(22):7084-8.[Pubmed link] [pdf]
Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempe D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R. Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. J Biol Chem. 2005 Jul 8;280(27):25517-23.[Pubmed link] [pdf]
Moncunill G, Negredo E, Bosch L, Vilarrasa J, Witvrouw M, Llano A, Clotet B, Este JA . Evaluation of the anti-HIV activity of statins. AIDS. 2005 Oct 14;19(15):1697-700. [Pubmed link] [pdf]
Tsotinis A, Vlachou M, Eleutheriades A, Garratt PJ, Ibbett AJ, Ng YF, Pannecouque C, Witvrouw M, De Clercq E. Aromatic polycationic molecules with restricted conformations: An alternative approach to antiherpes agents Lett. Drug Design & Discovery 2 (5): 424-427, Aug 2005. [no Pubmed] [no pdf]
2004
Barreca ML, Rao A, De Luca L, Zappala M, Gurnari C, Monforte P, De Clercq E, Van Maele B, Debyser Z, Witvrouw M, Briggs JM, Chimirri A. Efficient 3D database screening for novel HIV-1 IN inhibitors. J Chem Inf Comput Sci. 2004 Jul-Aug;44(4):1450-1455. [Pubmed link] [pdf] [supp. info.]
Fikkert V, Hombrouck A, Van Remoortel B, De Maeyer M, Pannecouque C, De Clercq E, Debyser Z, Witvrouw M. Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS. 2004 Oct 21;18(15):2019-2028. [Pubmed link] [pdf]
Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A. Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase (IN) interactor LEDGF/p75. J Biol Chem. 2004; 279(32):33421-9. [Pubmed link] [pdf]
van Griensven J, Zhan X, Van Maele B, Pluymers W, Michiels M, De Clercq E, Cherepanov P, Debyser Z. Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. J. Gene Medicine 6:268-277. [Pubmed link] [pdf]
Witvrouw M, Pannecouque C, Switzer WM, Folks TM, De Clercq E, Heneine W. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir Ther. 2004 Feb ;9 (1):57-65. [Pubmed link] [pdf]
Witvrouw M, Van Maele B, Vercammen J, Hantson A, Engelborghs Y, De Clercq E, Pannecouque C, Debyser Z. Novel inhibitors of HIV-1 integration. Curr Drug Metab. 2004 Aug;5(4):291-304.[Pubmed link] [pdf]
Ferro S, Rao A, Zappala M, Chimirri A, Barreca ML, Witvrouw M, Debyser Z, Monforte P. Synthesis of new potential HIV-1 integrase inhibitors. HETEROCYCLES 63 (12): 2727-2734 DEC 1 2004. [Pubmed link] [pdf]
Maruyama T, Kozai S, Demizu Y, Witvrouw M, Pannecouque C, Balzarini J, Snoecks R, Andrei G, De Clercq E. Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1. Nucleic Acids Symp Ser (Oxf). 2004;(48):3-4. [Pubmed link] [pdf]
Taymans JM , Kia HK, Claes R, Cruz C, Leysen J, Langlois X. Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time. Eur J Neurosci. 2004 Apr;19(8):2249-60. [Pubmed link] [pdf]
2003
Debyser Z. Biosafety of lentiviral vectors. Current Gene Therapy 3, 517-525. [Pubmed link] [pdf]
Debyser Z. A short course on virology/vectorology/gene therapy. Current Gene Therapy 3, 495-499.[Pubmed link] [pdf]
Van den Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V. Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knock-down of gene expression in mouse brain. Human Gene Therapy 14, 1799-1807. [Pubmed link] [pdf]
Baekelandt V, Eggermont K, Michiels M, Nuttin B, Debyser Z. Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain. Gene Therapy 10, 1933-1940. [Pubmed link] [pdf]
Fikkert V, Van Maele B, Vercammen J, Hantson A, Van Remoortel B, Michiels M, Gurnari C, Pannecouque C, De Maeyer M , Engelborghs Y, De Clercq E, Debyser Z, Witvrouw M. Development of resistance against diketo derivatives of human immunodeficiency virus-1 by progressive accumulation of mutations in integrase. J Virology 77(21):11459-70. [Pubmed link] [pdf]
Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 278, 33528-39. {6.9} [Pubmed link] [pdf]
Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V. Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of a -synuclein. Brain Pathology 13, 364-372 (2003). {5.6}[Pubmed link] [pdf]
Lagoja IM, Pannecouque C, Van Aerschot A, Witvrouw M, Debyser Z, Balzarini J, Herdewijn P, De Clercq E. N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. J Med Chem, 46(8): 1546-1553.[Pubmed link] [no pdf]
Van Maele B, De Rijck J, De Clercq E, Debyser Z. Impact of the central polypurine tract on the kinetics of HIV-1 vector transduction. J. Virol. 77(8):4685-94. {5.9}[Pubmed link] [pdf]
Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z. HIV -1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J. Biol. Chem. 278, 372-381 (2003). {6.9}[Pubmed link] [pdf]
Witvrouw M, Pannecouque C, Fikkert V, Hantson A, Van Reemortel B, Hezareh M, De Clerck E, Brown SJ. Potent and Selective inhibition of HIV and SIV by prostratin interacting with viral entry. Antivir Chem Chemother 14:321-328. [Pubmed link] [pdf]
Maruyama T, Kozai S, Yamasaki T, Witvrouw M, Pannecouque C, Balzarini J, Snoeck R, Andrei G, De Clercq E. Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV. Antivir Chem Chemother 14(5):271-9. [Pubmed link] [no pdf]
Stamatiou G, Foscolos GB, Fytas G, Kolocouris A, Kolocouris N, Pannecouque C, Witvrouw M, Padalko E, Neyts J, De Clercq E. Heterocyclic rimantadine analogues with antiviral activity. Bioorg Med Chem. 2003 Dec 1;11(24):5485-92. [Pubmed link] [pdf]
Galtier C, Mavel S, Snoeck R, Andrei G, Pannecouque C, Witvrouw M, Balzarini J, De Clercq E, Gueiffier A. Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives. Antivir Chem Chemother. 2003 Jul;14(4):177-82. [Pubmed link] [no pdf]
Esquieu D, Peloponese JM, Opi S, Gregoire C, de Mareuil J, Watkins J, Campbell G, Dunot JP, Sturgis J, Witvrouw M, Pannecouque C, de Clercq E, Montembault M, Giang VT, Villieras M, Fargeas V, Lebreton J, Loret EP. Discovery of a Tat HIV-1 inhibitor through computer-aided drug design. SPECTROSCOPY-AN INTERNATIONAL JOURNAL 17 (4): 639-645 2003. [abstract only available on web of science] [no pdf]
Anastasi C, Vlieghe P, Hantz O, Hantz O, Schorr O, Pannecouque C, Witvrouw M, De Clercq E, Clayette P, Dereuddre-Bosquete N, Dormont D, Gondois-Rey F, Hirsch I, Kraus JL. Are 5 '-O-Carbamate-2 ',3 '-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs? BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13 (15): 2459-2463 AUG 4 2003. [Pubmed link] [pdf]
Okamoto M, Wang X, Debyser Z, De Clercq E, Baba M. Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. J Virol Methods. 2003 Mar;108(2):195-203. [Pubmed link] [pdf]
Taymans JM , Leysen JE, Langlois X. Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions. J Neurochem. 84(5):1118-27. [Pubmed link] [no pdf]
2002
Fikkert V, Cherepanov P, Van Laethem K, Hantson A, Van Remoortel B, Pannecouque C, De Clercq E, Debyser Z, Vandamme AM, Witvrouw M. env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrob. Agents Chemother. 46, 3954-3962 (2002). {4.6} [Pubmed link] [pdf]
Debyser Z, Cherepanov P, Van Maele B, De Clercq E, Witvrouw M. In search of authentic inhibitors of HIV-1 integration. Antivir. Chem. Chemother. 13, 1-15. {1.4} [Pubmed link] [pdf]
Pluymers W, Pais G, Van Maele B, Pannecouque C, Fikkert V, Burke TR, De Clercq E, Witvrouw M, Neamati N, Debyser Z. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrob. Agents Chemother. 46, 3292-3297. {4.6} [Pubmed link] [pdf]
Pannecouque C, Pluymers W, Van Maele B, Tetz V, Cherepanov P, De Clercq E, Witvrouw M, Debyser Z. New class of HIV integrase inhibitors that block viral replication in cell culture. Current Biology. 12, 1169-1177. {7.5} [Pubmed link] [pdf]
Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser, Z. Characterization of lentiviral vector mediated gene transfer in adult mouse brain. Human Gene Therapy 13, 841-853 (2002). {6.8} [Pubmed link] [pdf]
Tenenbaum L, Chtarto A, Lehtonen E, Blum D, Baekelandt V, Velu T, Brotchi J, Levivier M. Neuroprotective Gene Therapy for Parkinson’s disease. Current Gene Therapy , 2 (4), 451-483. [Pubmed link] [no pdf]
Vercammen J, Maertens G, Gerard M, De Clercq E, Debyser Z, Engelborghs Y.DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy. J Biol Chem. 2002 Oct 11;277(41):38045-52. [Pubmed link] [pdf]
Moukha-chafiq O, Taha ML, Lazrek HB, Vasseur JJ, Pannecouque C, Witvrouw M, De Clercq E. Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4&5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines
FARMACO 57 (1): 27-32. [Pubmed link] [pdf]
Kritsanida M, Mouroutsou A, Marakos P, Pouli N, Papakonstantinou-Garoufalias S, Pannecouque C, Witvrouw M, De Clercq E. Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles FARMACO 57 (3): 253-257. [Pubmed link] [pdf]
Salido S, Altarejos J, Nogueras M, Sanchez A, Pannecouque C, Witvrouw M, De Clercq E. CHemical studies of essential oils of Juniperus oxycedrus ssp badia. J Ethnopharmacology 81 (1): 129-134. [Pubmed link] [pdf]
Cos P, Hermans N, De Bruyne T, Apers S, Sindambiwe JB, Witvrouw M, De Clercq E, Berghe DV, Pieters L, Vlietinck AJ. Antiviral activity of Rwandan medicainal plants against human immounodeficiency virus type-1 (HIV-1). Phytomedicine, 9(1): 62-68. [Pubmed link] [pdf]
Kolocouris A, Dimas K, Pannecouque C, Witvrouw M, Foscolos GB, Stamatiou G, Fytas G, Zoidis G, Kolocouris N, Andrei G, Snoeck R, De Clercq E. New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation. Bioorg Med Chem Lett. 2002 Mar 11;12(5):723-7. [Pubmed link] [pdf]
Vlieghe P, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Kraus JL. Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities. J Med Chem. 2002 Mar 14;45(6):1275-83.[Pubmed link] [pdf]
Bergstrom DE, Lin X, Wood TD, Witvrouw M, Ikeda S, Andrei G, Snoeck R, Schols D, De Clercq E. Polysulfonates derived from metal thiolate complexes as inhibitors of HIV-1 and various other enveloped viruses in vitro. Antivir Chem Chemother. 2002 May;13(3):185-95. [Pubmed link] [pdf]
Mishra V, Pandeya SN, Pannecouque C, Witvrouw M, De Clercq E. Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone. Arch Pharm (Weinheim). 2002 May;335(5):183-6. [Pubmed link] [pdf]
Taymans JM , Wintmolders C, Te Riele P, Jurzak M, Groenewegen HJ, Leysen JE, Langlois X. Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain. Neuroscience 114(1):39-53. [Pubmed link] [pdf]