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Current Projects

National Projects

NeuroTarget - IWT SBO. Integrated platform for target identification, validation and drug discovery with applications for neurodegenerative diseases. From January 2009 to December 2012 Prof. V. Baekelandt in collaboration with J. Winderickx , P. Chaltin, S. Sarre (VUB), C. Van Broeckhoven. (UA)
SBO Interactomics. From 2010 till 2014. Prof. L. Schoofs in collaboration with Z. Debyser, V. Baekelandt, R. Lavigne and J. Neyts.
SBO Optobrain. From November 2011 till October 2015. Coordinated by Zeger Debyser in collaboration with Pete Hegemann, Wolgfang Eberle, Wim Vanduffel, Detlef Balschun, Veerle Baekelandt, Lutgarde Arckens, Lieve Moons.
FWO G.0666.09N: "Structural en functional study of the central GTPase/kinase catalytic nucleus of LRRK2, a protein linked with Parkinson’s Disease." From January 2009 till December 2012. Prof. V. Baekelandt in collaboration with S. Strelkow, J.-M. Taymans
FWO G.0487.10N: "Molecular mechanism of Transportin-SR2 mediated nuclear import of HIV". From January 2010 till December 2013. Project leader is prof. Debyser, co-supervisor is Dr. Frauke Christ.
FWO G.0768.10: "The functional study of the pathophysiological role of alpha-synuclein aggregation in cellular and animal models for Parkinson's Disease". From January 2010 till December 2013. Project leader is prof. Baekelandt.
FWO G.0444.11: "Ocostatine M as master regulator of CZS pathology" From January 2011 till December 2014. Project leader is prof. Niels Hellings (UH), in collaboration with: Helena Slaets (UH), prof. Baekelandt (KULeuven), Sven Hendrix and Jerome Hendriks (UH).
FWO G.0682.12: From January 2012 till December 2015.
IOF-KP/07/008: "Technological platform for validation of new cofactors of HIV as antiviral target and identification and development of drugs again validated co-factors (CellCoHIV)". From October 2007 till September 2012. Prof. Debyser in collaboration with prof. Engelborghs, prof. Strelkov and dr. Patrick Chaltin (and formerly prof. Witvrouw).
OT/08/052A: "Multidisciplinary approach to study Parkinsons Disease: from basic neurobiology to development and validation of novel model systems and therapeutic strategies." From October 2008 till September 2012. Coordinator: V. Baekelandt. In collaboration with prof. Winderickx, Callewaert, prof. Van Laere, prof. Debyser and prof. Engelborghs.
OT/09/047: "On the cell biology of retroviral integration". From October 2009 till September 2013 Coordinator: Z. Debyser - co-supervisors: Frauke Christ, Jan De Rijck, Rik Gijsbers Funding agency: K.U.Leuven, Research Council
moSAIC: molecular Small Animal Imaging Centre of the K.U.Leuven. A collaborative project with prof. Mortelmans, prof. Himmelreich, prof. Van Laere, prof. Debyser, prof. Baekelandt, prof. Verbruggen.
IMIR: In vivo Molecular Imaging Research group K.U.Leuven. The IMIR consortium has been selected as a centre of excellence at the K.U.Leuven. The coordinator is prof. Guy Bormans (Laboratory for Radiopharmacy) and is collaboration with Department of Nuclear Medicine, Radiology Department, Division of Molecular Medicine and the Medical Imaging Research Center. Campuskrant

International Projects

THINC - EU FP7 - "Targeting HIV Integration Co-Factors, targeting cellular proteins during nuclear import or integration of HIV". From March 2008 to February 2011. The consortium consists of 9 legal entities with prof. Zeger Debyser as coordinator.
CHAARM EU FP7 - Combined Highly Active Anti-retroviral Microbicides. Coordinated by Ch. Kelly of the King's College of London. A consortium of 30 partners. From January 2010 till December 2014.
Neuromodel EU FP7 Marie Curie - "Initial Training Network on therapeutic approaches and predictive models for neurodegenerative diseases." Our part is the development of new rodent models based on familial PD genes using lentiviral vector technology and RNA interference.
MEFOPA EU FP7 Project on "Mendelian Forms of Parkinson’s Disease". Coordinated by Thomas Gasser of Eberhard Karls Universität Tübingen. From April 2010 till March 2013.

Former Projects

National Projects

BrainStim - IWT SBO. Non-invasive imaging of migration and survival of stem cells in the brain From January 2008 to December 2011 Prof. C. Verfaillie in collaboration with V. Baekelandt, K. Van Laere, S. De Smedt (UGent), A. Vanderlinden (UA).
	CellCoVir - IWT SBO (60813). Cellular co-factors of HIV: protein-protein interactions as novel drug targets In collaboration with Ghent University and CD3. From December 2007 to November 2011. Project leader was prof. Zeger Debyser.
AniMoNe - IWT SBO: "Development and non-invasive monitoring of new animal models based on local somatic transgenesis for better diagnosis and therapy of neurodegenerative diseases". From December 2003 to November 2007. Project leader was prof. Zeger Debyser.
FCS - IWT SBO: "Fluorescence Correlation Spectroscopy for the evaluation and valorisation of drug-target interactions in the living cell". From October 2003 to October 2007. The coordinator was Yves Engelborghs.
FWO G.0484.08:"Therapeutic potential of endogenous adult neural stem cells in animal models for Parkinson's disease". From January 2008 to December 2011. Prof. Baekelandt in collaboration with prof. Debyser.
FWO G.0114.08: "Research on prolyl oligopeptidase as therapeutic target for neuropathological diseases: blockers, substrates and ligands". From January 2008 to December 2011. Project leader is prof. Baekelandt.
FWO G.0406.06: "The role of new identified genes in molecular pathogenesis in Parkinson's Disease". From January 2006 to December 2009. Project leader was prof. Baekelandt.
Fund for Scientific Research Flanders, FWO, G.0164.03: "Study of the role of alpha-synuclein and parkin in the pathogenesis of Parkinson's disease using lentiviral vector technology". Project leader was prof. Baekelandt. From January 2005 to December 2007.
IOF-KP/07/001: KUL-PARK: "Technological platform for validation of new therapeutic targets for Parkinson's disease and development of drugs against validated targets". Prof. Baekelandt in collaboration with prof. Debyser, prof. Joris Winderickx, prof. Koen Van Laere, prof. Engelborghs. From October 2007 till September 2011.
IDO/06/006: "Study of the development of petidomimetics for the inhibiton of the interaction between HIV-integrase and the cellular co-factor LEDGF/p75." From December 2006 till 30.11.2011 Coordinator: E. Van der Eycken Research partners: Z. Debyser, M. De Mayer Funding agency: KU Leuven, IDO (Interdisciplinary Research Programmes)

International Projects

DiMI - EU FP6 - Network of Excellence: "Identification of new in vivo molecular imaging markers for diagnostic purposes". From April 2005 to September 2010 (extended for 6 months). The consortium consists of 59 partners with its coordinating centre in Cologne.
ExCellENT-HIT - EU FP6 - Specific Targeted Research and Innovation Project. "From November 2006 to October 2008. The consortium consisted of 6 legal entities with Myriam Witvrouw and Zeger Debyser as coordinators.
TRIoH - EU FP6 - Integrated Project: "Targeting Replication and Integration of HIV". From January 2004 to June 2007 (extended). The consortium consisted of 25 legal entities with Myriam Witvrouw as coordinator.
(N)Europark - EU FP5: "European network to develop new therapeutic strategies for Parkinson's disease using lentiviral vector technology". From January 2003 to June 2006. The consortium consisted of 3 legal entities with Veerle Baekelandt as coordinator.