Division of Molecular Medicine
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List of publications of Prof. Veerle Baekelandt

Baekelandt V, Arckens L, Annaert W, Eysel UT, Orban GA, Vandesande F. (1994) Alterations in GAP-43 and synapsin immunoreactivity provide evidence for synaptic reorganization in adult cat dorsal lateral geniculate nucleus following retinal lesions. Eur. J. Neurosci., 6,754-765. [abstract] [no pdf]

Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z (2000). DNA-dependent protein kinase is not required for efficient lentiviral integration. J. Virology 74, 11278-11285. {5.9} [abstract] [pdf]

Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser, Z (2002). Characterization of lentiviral vector mediated gene transfer in adult mouse brain. Human Gene Therapy 13, 841-853 (2002). {6.8} [abstract] [pdf]

Baekelandt V, De Strooper B, Nuttin B, Debyser Z (2000). Gene therapeutic strategies for neurodegenerative diseases. Current Opinion in Molecular Therapeutics 2, 540-554. [abstract] [pdf]

Baekelandt V, Eggermont K, Michiels M, Nuttin B, Debyser Z. Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain. Gene Therapy 10, 1933-1940. [abstract] [pdf]

Baekelandt V, Eysel UT, Orban GA, Vandesande F (1996). Long-term effects of retinal lesions on growth-associated protein 43 (GAP-43) expression in the visual system of adult cats. Neurosci. Lett., 208, 113-116. [abstract] [pdf]

Baekelandt V, Moechars D, Laenen I, Lorent K, Van Leuven F (1999). Disturbance of the glutamatergic system in mice transgenic for the amyloid precursor protein. Alzheimer’s Reports , 2, 359-368. [no PubMed] [no pdf]

Brandt I, Gérard M, Sergeant K, Devreese B, Baekelandt V, Augustyns K, Scharpé S, Engelborghs Y, Lambeir AM. Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein. Peptides May 15 [Epub ahead of print]. [abstract] [pdf]

Casteels C, Vermaelen P, Nuyts J, Van Der Linden A, Baekelandt V, Mortelmans L, Bormans G, Van Laere K. Construction and evaluation of Multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. J Nucl Med. 2006 Nov;47(11):1858-66. [abstract] [pdf]

Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen SJ, de Groot TJ, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and preliminary evalDebyser Zuation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 50(5):1041-9. [abstract] [no-pdf]

Chitneni SK, Deroose CM, Fonge H, Gijsbers R, Dyubankova N, Balzarini J, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of an (123)I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett.2007. Epub. [abstract] [pdf]

Deroose CM, Reumers V, Gijsbers R, Debyser Z, Bormans G, Mortelmans L, Baekelandt V (2006). Noninvasive Monitoring of Long-Term Lentiviral Vector-Mediated Gene Expression in Rodent Brain with Bioluminescence Imaging. Mol Ther. 2006; Epub Jun 30. [abstract] [pdf]

Debyser Z, De Vreese K, Knops-Gerrits PP, Baekelandt V, Bhikhabhai R, Strandberg B, Pauwels R, Anné J, Desmyter J, De Clercq E. Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors. Mol. Pharmacol., 43: 521-526 (1993). [abstract] [pdf]

Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z (2006). Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther. 2006 Jun;17(6):635-50. [abstract] [pdf]

Geraerts M, Krylychkina O, Debyser Z, Baekelandt V. Concise Review: Therapeutic strategies for Parkinson's disease based on the modulation of adult neurogenesis. Stem Cells 25(2):263-270. [abstract] [pdf]

Geraerts M, Michiels M, Baekelandt V, Debyser Z, Gijsbers R (2005). Upscaling of lentiviral vector production by tangential flow filtration. J Gene Med. 2005 Oct;7(10):1299-310. [abstract] [pdf]

Geraerts M, Willems S, Baekelandt V, Debyser Z, Gijsbers R. Comparison of lentiviral vector titration methods. BMC Biotechnol. 2006 Jul 12;6:34. [abstract] [pdf]

Gerard M, Debyser Z, Desender L, Baert J, Brandt I, Baekelandt V, Engelborghs Y. FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. J Neurochem. 2008 Apr 14 [Epub ahead of print]. [abstract] [pdf]

Gerard M, Debyser Z, Desender L, Kahle PJ, Baert J, Baekelandt V, Engelborghs Y (2006). The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB J. Mar;20(3):524-6. [abstract] [pdf]

Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem 2008; 283(24):16906-14. [abstract] [pdf]

Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B (1999). Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. PNAS, 96, 11872-7. [abstract] [pdf]

Irwin N, Baekelandt V, Goritchenko L, Benowitz LI (1997). Identification of two proteins that bind to a pyrimidine-rich sequence in the 3’-untranslated region of GAP-43 mRNA. Nucleic Acids Research, 25, 1281-1288. [abstract] [pdf]

Kronenberg G, Wang LP, Geraerts M, Babu H, Synowitz M, Vicens P, Lutsch G, Glass R, Yamaguchi M, Baekelandt V, Debyser Z, Kettenmann H, Kempermann G (2007).Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1. Brain Struct Funct 212(1):19-35. [abstract] [no pdf]

Lauwers E, Beque D, Van Laere K, Nuyts J, Bormans G, Mortelmans L, Casteels C, Vercammen L, Bockstael O, Nuttin B, Debyser Z, Baekelandt V (2007). Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging. 28:248-257. [abstract] [pdf]

Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V. Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of a -synuclein. Brain Pathology 13, 364-372 (2003). {5.6} [abstract] [pdf]

Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Tesseur I, Spittaels K, Naidu A, Van Den Haute C, Checler F, Godaux E, Cordell B, Van Leuven F. (1999) Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274: 6483-6492. {7.4} [abstract] [pdf]

Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F (1998). Transgenic mice expressing an a -secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research, 95, 55-64. [abstract] [pdf]

Reumers V, Deroose CM, Krylyshkina O, Nuyts J, Geraerts M, Mortelmans L, Gijsbers R, Van Den Haute C, Debyser Z, Baekelandt V. Non-invasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain using Bioluminescence Imaging. Stem Cells. 2008 Jul 3 [Epub ahead of print]. [abstract] [pdf]

Taymans JM, Van den Haute C, Baekelandt V (2006). Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem. 2006 Aug;98(3):951-61. [abstract] [pdf]

Taymans JM, Vandenberghe LH, Van den Haute C, Thiry I, Deroose CM, Mortelmans L, Wilson JM, Debyser Z, Baekelandt V. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther 18(3):195-206. [abstract] [pdf]

Tenenbaum L, Chtarto A, Lehtonen E, Blum D, Baekelandt V, Velu T, Brotchi J, Levivier M (2002). Neuroprotective Gene Therapy for Parkinson’s disease. Current Gene Therapy , 2 (4), 451-483. [abstract] [no pdf]

Van de Putte T, Zwijzen A, Lonnoy O, Rybin V, Cozijnsen M, Francis A, Baekelandt V, Kozak CA, Zerial M, Huylebroeck D. Mice with a homozygous gene trap vector insertion in gcRacGAP die during pre-implantation development. Mechanisms of Development, 102 (1-2), 33-44. {4.2} [abstract] [pdf]

Van den Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V (2003). Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knock-down of gene expression in mouse brain. Human Gene Therapy 14, 1799-1807. [abstract] [pdf]

Vercammen L, Van der Perren A, Vaudano E, Gijsbers R, Debyser Z, Van den Haute C, Baekelandt V. Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease. Mol Ther. 2006 Aug 14 [Epub ahead of print] [abstract] [pdf]