Division of Molecular Medicine
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List of publications of Prof. Zeger Debyser

Adams MM, Bats JW, Nikolaus NV, Witvrouw M, Debyser Z, Engels JW.Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase. Coll Czech Chem Comm 71 (7): 978-990, 2006. [abstract available on Web of Science] [pdf]

Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N. Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: Insight into integrase-DNA complex formation and catalysis. FEBS Lett. 582(10):1425-30. [abstract] [pdf]

Al-Mawsawi LQ, Dayam R, Taheri L, Witvrouw M, Debyser Z, Neamati N. Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. Bioorg Med Lett 17(23):6472-6472. [abstract] [pdf]

Baba M, Debyser Z, Shigeta S, De Clercq E. Highly potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by the HIV-1-specific reverse transcriptase inhibitors. Drugs of the Future, 17: 891-897 (1992). [no abstract] [no pdf]

Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z (2000). DNA-dependent protein kinase is not required for efficient lentiviral integration. J. Virology 74, 11278-11285. [abstract] [pdf]

Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser, Z (2002). Characterization of lentiviral vector mediated gene transfer in adult mouse brain. Human Gene Therapy 13, 841-853 (2002). {6.8} [abstract] [pdf]

Baekelandt V, De Strooper B, Nuttin B, Debyser Z (2000). Gene therapeutic strategies for neurodegenerative diseases. Current Opinion in Molecular Therapeutics 2, 540-554. [abstract] [pdf]

Baekelandt V, Eggermont K, Michiels M, Nuttin B, Debyser Z (2003). Optimized lentiviral vector production and purification procedure prevents immune response after transduction of rodent brain. Gene Therapy 10, 1933-1940. [abstract] [pdf]

Barreca ML, Ferro S, Rao A, De Luca L, Zappala M, Monforte AM, Debyser Z, Witvrouw M, Chimirri A (2005). Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. J Med Chem. 2005 Nov 3;48(22):7084-8. [abstract] [pdf]

Barreca ML, Rao A, De Luca L, Zappala M, Gurnari C, Monforte P, De Clercq E, Van Maele B, Debyser Z, Witvrouw M, Briggs JM, Chimirri A (2004). Efficient 3D database screening for novel HIV-1 IN inhibitors. J Chem Inf Comput Sci. 2004 Jul-Aug;44(4):1450-1455. [abstract] [pdf] [supp. info.]

Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F (2007). Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75. J Mol Bio 372(2):407-21. [abstract] [pdf]

Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z (2005). The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.J Biol Chem. 2005 May 6;280(18):17841-7. [abstract] [pdf]

Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F. Identification of the LEDGF/p75 binding site in HIV-1 integrase.
J mol biol (2007) 365, 1480–1492. [abstract] [pdf]

Celen S, Deroose C, de Groot T, Chitneni SK, Gijsbers R, Debyser Z, Mortelmans L, Verbruggen A, Bormans G. Synthesis and evaluation of 18F- and 11C-labelled phenyl-galactopyranosides as potential probes for in vivo visualization of lacZ gene expression using positron emission tomography. Bioconj. Chem. 19(2):441-9. [abstract] [no pdf]

Cherepanov P, Este JA, Rando RF, Ojwang JO, Reekmans G, Steinfeld R, David G, De Clercq E, Debyser Z (1997). Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1. Mol Pharmacol. 52(5):771-80. [abstract] [pdf]

Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z. HIV -1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J. Biol. Chem. 278, 372-381 (2003). {6.9} [abstract] [pdf]

Cherepanov P, Pluymers W, Claeys A, De Clercq E, Debyser Z (2000). High level expression of active HIV-1 integrase from a synthetic gene in human cells. FASEB J. 14, 1389-1399. [abstract] [pdf]

Cherepanov P, Surratt D, Toelen J, Pluymers W, Griffith J, Desmyter J, De Clercq E, Debyser Z (1999). Activity of recombinant HIV-1 integrase on mini-HIV DNA. Nucleic Acids Research 27, 2202-2210 (1999). [abstract] [pdf]

Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen SJ, de Groot TJ, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 50(5):1041-9. [abstract] [pdf]

Chitneni SK, Deroose CM, Balzarini J, Gijsbers R, Celen S, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. A p-[(18)F]Fluoroethoxyphenyl Bicyclic Nucleoside Analogue as a Potential Positron Emission Tomography Imaging Agent for Varicella-Zoster Virus Thymidine Kinase Gene Expression. J Med Chem. 2007 Nov 30 [Epub ahead of print] [abstract] [no pdf]

Chitneni SK, Deroose CM, Fonge H, Gijsbers R, Dyubankova N, Balzarini J, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of an (123)I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorg Med Chem Lett.2007. Epub. [abstract] [pdf]

Chitneni SK, Serdons K, Evens N, Fonge H, Celen S, Deroose CM, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. J Chromatogr A. 1189(1-2):323-31. [abstract] [pdf]

Dayam R, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem 51(5):1136-44. [abstract] [no pdf]

De Clercq E, Yamamoto N, Pauwels R, Baba M, Schols D, Nakashima H, Balzarini J, Debyser Z, Murrer BA, Schwartz D, Thornton D, Bridger G, Fricker S, Henson G, Abrams M, Picker D. Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. Proc. Natl. Acad. Sci. USA, 89: 5286-5290 (1992). [abstract] [pdf]

De Clercq E, Yamamoto N, Pauwels R, Balzarini J, Witvrouw M, De Vreese K, Debyser Z, Rosenwirth B, Datema R, Thornton D, Skerlj R, Bridger G, Henson G, Abrams M. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. Agents Chemother., 38, 668-674 (1994). [abstract] [pdf]

De Luca L, Barreca ML, Ferro S, Iraci N, Michiels M, Christ F, Debyser Z, Witvrouw M, Chimirri A. A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. Bioorg Med Chem Lett. 18(9):2891-5. [abstract] [pdf]

De Rijck J, Debyser Z. The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication. Biochem Biophys Res Commun. 2006;349(3):1100-10. [abstract] [pdf]

De Rijck J, Van Maele B, Debyser Z (2005). Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors. Biochem Biophys Res Commun. 2005 Mar 25;328(4):987-94. [abstract] [pdf]

De Rijck J, Vandekerckhove L, Christ F, Debyser Z. Lentiviral nuclear import: a complex interplay between virus and host. Bioessays. 29(5):441-51. [abstract] [pdf]

De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F, Debyser Z (2006). Overexpression of the lens epithelium-derived growth factor/p75 Integrase Binding Domain Inhibits HIV Replication. J Virol. 2006 80 (23): 11498-11506. [abstract] [pdf]

de Vreese K, Debyser Z, Vandamme AM, Pauwels R, Desmyter J, De Clercq E, Anné J. Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. Virology, 188: 900-904 (1992). [abstract] [no pdf]

Debyser Z (2003). Biosafety of lentiviral vectors. Current Gene Therapy 3, 517-525. [abstract] [pdf]

Debyser Z (1995). Novel DNA substrates for studying replication mechanisms. Synthetic replication forks. Methods in Enzymology, 262 : 457-466. [no abstract or pdf]

Debyser Z (2003). A short course on virology/vectorology/gene therapy. Current Gene Therapy 3, 495-499. [abstract] [pdf]

Debyser Z, Cherepanov P, Pluymers W, De Clercq E (2001). Assays for the evaluation of HIV-1 integrase inhibitors. Methods in Molecular Biology. Nucleases (Humana Press, Ed. C. H. Schein); 160, 139-155. [no abstract] [pdf]

Debyser Z, Cherepanov P, Van Maele B, De Clercq E, Witvrouw M (2002). In search of authentic inhibitors of HIV-1 integration. Antivir. Chem. Chemother. 13, 1-15. [abstract] [pdf]

Debyser Z, De Clercq E (1996). Antiviral therapy for HIV infection. EOS, Journal of Immunology and Immunopharmacology, 2 : vol. XVI. [no abstract or pdf]

Debyser Z, De Clercq E. Chemical crosslinking of the subunits of HIV-1 reverse transcriptase. Protein Science. 5 : 278-286 (1996). [abstract] [pdf]

Debyser Z, De Vreese K, Pauwels R, Yamamoto N, Anné J, De Clercq E, Desmyter J. Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus. J. Gen. Virol., 73: 1799-1804 (1992). [abstract] [no pdf]

Debyser Z, De Vreese K, Knops-Gerrits PP, Baekelandt V, Bhikhabhai R, Strandberg B, Pauwels R, Anné J, Desmyter J, De Clercq E. Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors. Mol. Pharmacol., 43: 521-526 (1993). [abstract] [pdf]

Debyser Z, Pauwels R, Andries K, De Clercq E. Specific HIV-1 reverse transcriptase inhibitors. J. Enzyme Inhibition, 6: 47-53 (1992). [no abstract] [no pdf]

Debyser Z, Pauwels R, Andries K, Desmyter J, Engelborghs Y, Janssen PAJ, De Clercq E. Allosteric inhibition of HIV-1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds. Mol. Pharmacol., 41: 203-208 (1992). [abstract] [pdf]

Debyser Z, Pauwels R, Andries K, Desmyter J, Kukla M, Janssen PAJ, De Clercq E. An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione derivatives. Proc. Natl. Acad. Sci. USA, 88: 1451-1455 (1991). [abstract] [pdf]

Debyser Z, Pauwels R, Baba M, Desmyter J, De Clercq E. Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase. Mol. Pharmacol 41: 963-969 (1992). [abstract] [pdf]

Debyser Z, Reynders M, Goubau P, Desmyter J. Comparison of three ELISA techniques and an indirect immunofluorescense assay for the serological diagnosis of Epstein-Barr virus infection. Clinical and Diagnostic Virology, 8 : 71-81 (1997). [abstract] [pdf]

Debyser Z, Tabor S, Richardson CC. Coordination of leading and lagging strand synthesis at the replication fork of bacteriophage T7. Cell, 77, 157-166 (1994). [abstract] [no pdf]

Debyser Z, Van Wijngaerden E, Van Laethem K, Beuselinck K, Reynders M, De Clercq E, Desmyter J, Vandamme AM. Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain. AIDS Research and Human Retroviruses, 14, 453-459. {3} [abstract] [no pdf]

Debyser Z, Vandamme A, Pauwels R, Baba M, Desmyter J, De Clercq E. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiaze-pin-2(1H)-thione, and 1-[(2-hydroxyethoxy)methyl]-6-(phenyl-thio)thymine derivatives. J Biol Chem 267: 11769-11776 (1992). [abstract] [pdf]

Deroose CM, Reumers V, Gijsbers R, Debyser Z, Bormans G, Mortelmans L, Baekelandt V (2006). Noninvasive Monitoring of Long-Term Lentiviral Vector-Mediated Gene Expression in Rodent Brain with Bioluminescence Imaging. Mol Ther. 2006; Epub Jun 30. [abstract] [pdf]

Dubois M, Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. Reaction of Rosmarinic Acid with Nitrite Ions in Acidic Conditions: Discovery of Nitro- and Dinitrorosmarinic Acids as New Anti-HIV-1 Agents. J Med Chem 51(8):2575-9. [abstract] [no pdf]

Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempe D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R (2005). Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. J Biol Chem. 2005 Jul 8;280(27):25517-23. [abstract] [pdf]

Esté JA, Cabrera C, Schols D, Cherepanov P, Gutierrez A, Witvrouw M, Pannecouque C, Debyser Z, Rando RF, Clotet B, Desmyter J, De Clercq E. Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (zintevir). Mol. Pharmacol., 53, 340-345. {4.9} [abstract] [pdf]

Ferro S, Barreca ML, De Luca L, Rao A, Monforte AM, Debyser Z, Witvrouw M, Chimirri A. New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors. Arch Pharm (Weinheim) 340(6):292-8. [abstract] [pdf]

Ferro S, Rao A, Zappala M, Chimirri A, Barreca ML, Witvrouw M, Debyser Z, Monforte P (2004).
Synthesis of new potential HIV-1 integrase inhibitors. HETEROCYCLES 63 (12): 2727-2734 DEC 1 2004. [abstract] [pdf]

Fikkert V, Cherepanov P, Van Laethem K, Hantson A, Van Remoortel B, Pannecouque C, De Clercq E, Debyser Z, Vandamme AM, Witvrouw M (2002). env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrob. Agents Chemother. 46, 3954-3962 (2002). [abstract] [ pdf]

Fikkert V, Hombrouck A, Van Remoortel B, De Maeyer M, Pannecouque C, De Clercq E, Debyser Z, Witvrouw M (2004). Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS. 2004 Oct 21;18(15):2019-2028. [abstract] [pdf]

Fikkert V, Van Maele B, Vercammen J, Hantson A, Van Remoortel B, Michiels M, Gurnari C, Pannecouque C, De Maeyer M , Engelborghs Y, De Clercq E, Debyser Z, Witvrouw M. Development of resistance against diketo derivatives of human immunodeficiency virus-1 by progressive accumulation of mutations in integrase. J Virology 77(21):11459-70. [abstract] [pdf]

Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z (2006). Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther. 2006 Jun;17(6):635-50. [abstract] [pdf]

Geraerts M, Krylychkina O, Debyser Z, Baekelandt V. Concise Review: Therapeutic strategies for Parkinson's disease based on the modulation of adult neurogenesis. Stem Cells 25(2):263-270. [abstract] [pdf]

Geraerts M, Michiels M, Baekelandt V, Debyser Z, Gijsbers R (2005). Upscaling of lentiviral vector production by tangential flow filtration. J Gene Med. 2005 Oct;7(10):1299-310. [abstract] [pdf]

Gerard M, Debyser Z, Desender L, Baert J, Brandt I, Baekelandt V, Engelborghs Y. FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. J Neurochem. 2008 Apr 14 [Epub ahead of print] [abstract] [pdf]

Gerard M, Debyser Z, Desender L, Kahle PJ, Baert J, Baekelandt V, Engelborghs Y (2006). The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB J. 20(3):524-6. [abstract] [pdf]

Geraerts M, Willems S, Baekelandt V, Debyser Z, Gijsbers R. Comparison of lentiviral vector titration methods. BMC Biotechnol. 2006 Jul 12;6:34. [abstract] [pdf]

Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G , De Clercq E , Vandamme AM , Debyser Z , Witvrouw M (2005). Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology. Antivir Chem Chemother. 2005;16(4):253-66. [abstract] [pdf]

Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z (2007). Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV. PLoS Pathog 3(3): e47. [abstract] [free full text]

Hombrouck A, Hantson A, Van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M (2007). Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action. J Antimicrob Chemother 59(6):1084-95. [abstract] [pdf]

Hombrouck A, Van Remoortel B, Michiels M, Noppe W, Christ F, Eneroth A, Sahlberg BL, Benkestock K, Vrang L, Johansson NG, Barreca ML, De Luca L, Ferro S, Chimirri A, Debyser Z, Witvrouw M. Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Stran Transfer Inhibitors. Antimicrob Agents Chemother 52(8). [abstract] [pdf]

Hombrouck A, Voet A, Van Remoortel B, Desadeleer C, De Maeyer M, Debyser Z, Witvrouw M. Mutations in HIV-1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross Resistance to the Clinical Trial drug GS-9137. Antimicrob Agents Chemother. 2008 Mar 31 [Epub ahead of print] [abstract] [pdf]

Jonckheere H, De Vreese K, Debyser Z, Vandekerckhove J, Balzarini J, Desmyter J, De Clercq E, Anne J (1996). A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. J Virol Methods. 61(1-2):113-25. [abstract] [pdf]

Kronenberg G, Wang LP, Geraerts M, Babu H, Synowitz M, Vicens P, Lutsch G, Glass R, Yamaguchi M, Baekelandt V, Debyser Z, Kettenmann H, Kempermann G.Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1. Brain Struct Funct 212(1):19-35. [abstract] [no pdf]

Lagoja IM, Pannecouque C, Van Aerschot A, Witvrouw M, Debyser Z, Balzarini J, Herdewijn P, De Clercq E (2003). N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. J Med Chem, 46(8): 1546-1553. [abstract] [no pdf]

Lauwers E, Beque D, Van Laere K, Nuyts J, Bormans G, Mortelmans L, Casteels C, Vercammen L, Bockstael O, Nuttin B, Debyser Z, Baekelandt V (2007). Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging. 28:248-257. [abstract] [pdf]

Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V (2003). Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of a -synuclein. Brain Pathology 13, 364-372 (2003). [abstract] [pdf]

Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, De Clercq E, Rice WG, Pommier Y, Burke TR (1999). Chicoric acid analogues as HIV-1 integrase inhibitors. J. Medicinal Chemistry 42, 1404-1414. [abstract] [pdf]

Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A (2004). Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase (IN) interactor LEDGF/p75. J Biol Chem. 2004; 279(32):33421-9. [abstract] [pdf]

Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y (2003). LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 278, 33528-39. {6.9} [abstract] [pdf]

Maertens G, Vercammen J, Debyser Z, Engelborghs Y (2005). Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75. FASEB J. 2005 Jun;19(8):1039-41. [abstract] [pdf]

Mugnaini C, Rajamaki S, Tintori C, Corelli F, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies. Bioorg Med Chem Lett 17(19):5370-3. [abstract] [pdf]

Oelrichs RB, Vandamme AM, Van Laethem K, Debyser Z, McCutchan FE, Deacon NJ (1999). Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa. AIDS Research and Human Retroviruses 15, 585-589. [PubMed] [pdf]

Okamoto M, Wang X, Debyser Z, De Clercq E, Baba M (2003). Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. J Virol Methods. 2003 Mar;108(2):195-203. [abstract] [pdf]

Pannecouque C, Pluymers W, Van Maele B, Tetz V, Cherepanov P, De Clercq E, Witvrouw M, Debyser Z (2002). New class of HIV integrase inhibitors that block viral replication in cell culture. Current Biology. 12, 1169-1177. {7.5} [abstract] [pdf]

Park K, Debyser Z, Tabor S, Richardson CC, Griffith JD. Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteinscteriophage proteins. J. Biol. Chem. 273, 5260-5270. {6.9} [abstract] [pdf]

Pauwels R, Andries K, Debyser Z, Kukla M, Schols D, Desmyter J, De Clercq E, Janssen PAJ. TIBO derivatives : a new class of highly potent and specific inhibitors of HIV-1 replication. Biochem. Soc. Trans., 20: 509-512 (1992). [no abstract] [no pdf]

Pauwels R, Andries K, Debyser Z, Van Daele P, Schols D, Stoffels P, De Vreese K, Woestenborghs, Vandamme AM, Janssen CGM, Anné J, Cauwenbergh G, Desmyter J, Heykants J, Janssen MAC, De Clercq E, Janssen PAJ. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alfa-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proc. Natl. Acad. Sci. USA, 90: 1711-1715 (1993). [abstract] [pdf]

Pauwels R, Andries K, Debyser Z, Kukla MJ , Schols D, Breslin HJ, Woestenborghs R, Desmyter J, Janssen MAC, De Clercq E, Janssen PAJ. New tetrahydroimidazo[4,5,1-jk] [1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of HIV-1 replication and are synergistic with 2',3'-dideoxynucleoside analogues. Antimicrob. Agents Chemother., 38 : 2863-2870 (1994). [abstract] [pdf]

Pauwels R, Debyser Z, Balzarini J, Baba M, Desmyter J, Rayner B, Morvan F, Imbach Jl, Declercq E. Alpha-oligodeoxynucleotides as inhibitors of hiv reverse-transcriptase. Nucleosides & nucleotides 8(5-6): 995-1000. [abstract in lirias] [no pdf]

Pluymers W, Cherepanov P, Schols D, De Clercq E, Debyser Z (1999). Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. Virology 258, 327-332. [abstract] [pdf]

Pluymers W, De Clercq E, Debyser Z (2001). HIV-1 integration as a target for antiretroviral therapy: a review. Current Drug Targets-Infectious Disorders 1, 133-149. [abstract] [pdf]

Pluymers W, Neamati N, Pannecouque C, Fikkert V, Marchand C, Burke TR Jr, Pommier Y, Schols D, De Clercq E, Debyser Z, Witvrouw M (2000). Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. Mol Pharmacol. 2000 Sep;58(3):641-8. [abstract] [pdf]

Pluymers W, Pais G, Van Maele B, Pannecouque C, Fikkert V, Burke TR, De Clercq E, Witvrouw M, Neamati N, Debyser Z (2002). Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrob. Agents Chemother. 46, 3292-3297. {4.6} [abstract] [pdf]

Queffélec C , Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. Eur J Med Chem. 2007 Dec 27 [Epub ahead of print]. [abstract] [pdf]

Reumers V, Deroose CM, Krylyshkina O, Nuyts J, Geraerts M, Mortelmans L, Gijsbers R, Van Den Haute C, Debyser Z, Baekelandt V. Non-invasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain using Bioluminescence Imaging. Stem Cells. 2008 Jul 3 [Epub ahead of print]. [abstract] [pdf]

Taymans JM, Vandenberghe LH, Van den Haute C, Thiry I, Deroose CM, Mortelmans L, Wilson JM, Debyser Z, Baekelandt V. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Hum Gene Ther 18(3):195-206. [abstract] [pdf]

Thormar H, Balzarini J, Holy A, Jindrich J, Dvorakova H, Debyser Z, Desmyter J, De Clercq, E. Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogues. Antimicrob. Agents Chemother., 37 : 2540-2544 (1993). [abstract] [pdf]

Tintori C, Manetti F, Veljkovic N, Perovic V, Vercammen J, Hayes S, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M (2007). Novel Virtual screening protocol based on the combine use of molecular modelling and electron-ion intereaction potential techniques to design HIV-1 integrase inhibitors. J. Chem Inf Model 47(4):1536-44. [abstract] [no pdf]

Toelen J, Gijsbers R, Sbragia L, Deroose C, Debyser Z, Deprest J. Long term pulmonary gene therapy with a lentiviral vector in a fetal rat model. Ultrasound Obstet Gynecol. 30(4):460. [pdf]

Toelen J, Deroose CM, Gijsbers R, Reumers V, Sbragia LN, Vets S, Chitnei SK, Bormans G, Mortelmans L, Deprest JA, Debyser Z. Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. Am J Obstet Gynecol 196(4):352.e1-6. [abstract] [pdf]

Vandamme AM, Debyser Z, Pauwels R, De Vreese K, Goubau P, Youle M, Gazzard B, Stoffels PA, Cauwenbergh GF, Anné J, Andries K, Janssen PAJ, Desmyter J, De Clercq E. Characterization of HIV-1 strains isolated from patients treated with TIBO R82913. AIDS Res. Human Retrovir., 10 : 39-46 (1994). [abstract] [no pdf]

Van de Putte T, Zwijzen A, Rybin V, Cozijnsen M, Francis A, Baekelandt V, Kozak CA, Zerial M, Huylebroeck D (2001). Mice with a homozygous gene trap vector insertion in gcRacGAP die during pre-implantation development. Mechanisms of Development, 102 (1-2), 33-44. {4.2} [abstract] [pdf]

Van den Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V (2003). Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knock-down of gene expression in mouse brain. Human Gene Therapy 14, 1799-1807. [abstract] [pdf]

van Griensven J, De Clercq E, Debyser Z (2005). Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. AIDS Rev. 2005 Jan-Mar;7(1):44-55. [abstract] [pdf]

van Griensven J, Zhan X, Van Maele B, Pluymers W, Michiels M, De Clercq E, Cherepanov P, Debyser Z (2004). Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. J. Gene Medicine 6:268-277. [abstract] [pdf]

Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z. Cellular co-factors of HIV-1 integration (2006). Trends Biochem Sci. 80(4):1886-96. [abstract] [pdf]

Van Maele B, De Rijck J, De Clercq E, Debyser Z (2003). Impact of the central polypurine tract on the kinetics of HIV-1 vector transduction. J. Virol. 77(8):4685-94. {5.9} [abstract] [pdf]

Van Maele B, Debyser Z (2005). HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. AIDS Rev. 7(1):26-43. [abstract] [pdf]

Van Maele B, Van Eylen L, Pluymers W, Debyser Z (2006). Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells. Biochem Biophys Res Commun. 4;327(1):261-7. [abstract] [pdf]

Vandamme AM, Van Laethem K, Schmit JC, Van Wijngaerden E, Reynders M, Debyser Z, Witvrouw, M, Van Ranst M, De Clercq E, Desmyter J (1999). Long-term stability of HIV viral load and infectivity in whole blood. Eur. J. of Clinical Investigation 29, 445-452. [abstract] [pdf]

Vandekerckhove L, Christ F, Van Maele B, De Rijck J, Gijsbers R, Van den Haute C, Witvrouw M, Debyser Z. Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol. 2006; 80(4):1886-96. [abstract] [pdf]

Vandekerckhove L, De Rijck J, Christ F, Gijsbers R, Debyser Z. RNAi-based treatment of HIV/AIDS: Current status and perspectives. Drug Discovery Today: Therapeutic Strategies 3(2): 227-235. [abstract] [pdf]

Veljkovic V, Mouscadet JF, Veljkovic N, Glisic S, Debyser Z. Simple criterion for selection of flavonoid compounds with anti-HIV activity. Bioorg Med Chem Lett. In press. [abstract] [pdf]

Vercammen J, Maertens G, Gerard M, De Clercq E, Debyser Z, Engelborghs Y (2002). DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy. J Biol Chem. 2002 Oct 11;277(41):38045-52. [abstract] [pdf]

Vercammen L, Van der Perren A, Vaudano E, Gijsbers R, Debyser Z, Van den Haute C, Baekelandt V. Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease. Mol Ther. 2006 Aug 14 [Epub ahead of print] [abstract] [pdf]

Witvrouw M, Balzarini J, Pannecouque C, Jhaumeer-Laulloo S, Esté J, Schols, D, Cherepanov P, Schmit JC, Debyser Z, Vandamme AM, Desmyter J, Ramadas R, De Cercq E (1997). SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Antimicrob. Agents Chemother., 41 : 262-268. [abstract] [pdf]

Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C (2000). Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. Mol. Pharmacol. 58, 1100-1108. {5.3} [abstract] [pdf]

Witvrouw M, Fikkert V, Vercammen J, Van Maele B, Engelborghs Y, Debyzer Z (2005). Identification of Authentic Inhibitors of HIV integration. Curr. Med. Chem. Anti-infective agents, 4 153-165. [no link to pubmed] [pdf]

Witvrouw M, Van Maele B, Vercammen J, Hantson A, Engelborghs Y, De Clercq E, Pannecouque C, Debyser Z (2004). Novel inhibitors of HIV-1 integration. Curr Drug Metab. 2004 Aug;5(4):291-304. [abstract] [pdf]

Yamamoto N, Schols D, De Clercq E, Debyser Z, Pauwels R, Balzarini J, Nakashima H, Baba M, Hosoya M, Snoeck R, Neyts J, Andrei G, Murrer BA, Theobald B, Bossard G, Henson G, Abrams M, Picker D. Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents. Mol. Pharmacol 42: 1109-1117 (1992). [abstract] [pdf]