Patient-oriented study of the factors impacting the long term outcome of patients with chronic nephropathies both before and after starting renal replacement therapy. - Mechanisms underlying the progression of chronic glomerulone- phritis. * Evaluation of new methods to follow long term renal function in men. * Role of chronic hyperfiltration - effect of pharmacological interventions. * Role of persisting proteinuria. * Place of immunosuppressive therapy in the progression of chronic glomerulonphritis. - Mechanisms underlying the occurence of accelerated atheroma- thosis in patients with chronic renal failure, patients in hemo- and peritoneal dialysis and recipients of a cadaveric renal graft. Specific role of oxidized LDL. - Factors responsible for the long term attrition of cadaveric renal allografts. This study is performed on a computized data base of almost 2.000 renal transplant patients. - Study of the impact of new immunosuppressive agents on the ear- ly and late outcome of renal transplantation. - Stufy of the protective effect of vitamine D therapy on the occurrence of accelerated osteoporosis in renal transplant re- cipients.
