1. Dental Composite Resins: The use of dental composite resins is studied in vivo and in vitro. - The in vivo study contains both a qualitative and a quantitative evaluation of the clinical performance of different systems among dental composite resins. The qualitative assessments are done according to an index system studying different parameters such as aesthetics, marginal adaptation, biocompatibility, adhesion to different dentine tissues and caries recurrence. The quantitative measurement of the wear resistance of posterior composite restorations is realized with tridimensional computerized microscopic equipment and by real-time contouring of tooth imprints by laser. - In the in vitro study, the mechanical characteristics such as dynamic E-modules under flexure is determined by a new non-destructive frequency measuring method. The new technique is suitable for monitoring influences of curing, polymerization process, ageing, thermal cycling, chemical aggressionand fatigue damage. 2. Medical dentistry: Experimental and clinical research in the field of medical dentistry: Blood loss following dental extractions in patients with compromised hemostasis; evaluation of local and systemic hemostatic techniques; oral pathology in acute leukemia; dental treatment of patients with acquired and/or induced immunodeficiency (special interest in transplant patients)
