1. Topical tacrolimus in atopic patients (H. Degreef & H. Morren) 2. Oral ascomycine in atopic adult patients, to start in 2001. This is a dose finding study and we also investigate the tolerability (H. Degreef & H. Morren). 3. Fragrance chemical allergy : a major environmental and consumer health problem in Europe (A. Goossens). 4. Contact allergy to limonene (A. Goossens). 5. Characteristics of vit D in epidermal keratinocytes. UVB induced production of active vit D. Regulation of the expression of vit D receptor and enzymes, interfering with the synthesis and metabolism of vit D (S. Segaert, working in the department of Legendo of prof. Bouillon). 6. Responses of keratinocytes after UVB damage of these cells. - Nutrition as a systemic protector. - The role of P53. - Signal transduction resulting in UVB induced apoptosis (M. Garmyn).