Methusalem Funding >Angiogenesis and neurovascular links

Angiogenesis and neurovascular links

Coordinator	Prof. Peter Carmeliet
Methusalem Group	Prof. Diether Lambrechts Prof. Mieke Dewerchin Prof. Wim Robberecht Prof. Ludo Van Den Bosch Prof. Eric Van Cutsem Prof. Sabine Tejpar Prof. Chris Verslype Prof. Jan Cools Prof. Thomas Voets Prof. Bernd Nilius
Centre	Vesalius Research Center
Starting date	October 1st 2007
Financing	EUR 950.000 per year

Summary

The purpose is (1) Further unravelling the genetic basis of angiogenesis; by discovering novel angiogenic genes and studying their function in vivo; by screening, identifying and evaluating the therapeutic potential of novel (“in house developed”) angiogenesis inhibitors preclinically and clinically and, via strategies from the bench to the bedside and back again, improve the overall efficacy of and reduce the resistance to anti-angiogenic treatments. (2) Studying the neurovascular link: by identifying the molecular mechanisms of, and in particular defining the role of the VEGF family and other angiogenic genes, in development and neurodegeneration; by developing additional VEGF-based therapeutic strategies preclinically and evaluating the therapeutic potential of VEGF for ALS clinically.

Motivation by the University Board