|
In vitro evaluation of hepatic disposition (metabolism, hepatic transport, biliary excretion) of drugs and other small molecules
|
| Description expertise techniques : |
1. Suspended or plated hepatocyte cultures of rat, dog, pig and human (other species possible). Plated hepatocytes are typically cultured in a sandwich-configuration (between two layers of collagen).
2. subcellular fractions of liver of various species
3. In vivo bile excretion studies
4. Bioanalytical techniques to support the above (HPLC with UV or fluorescence detection, direct analyis by fluorescence in plate reader, liquid scintillation counting for 3H- or 14C-labelled compounds)
|
| Description expertise users : |
| |
Research team to which
ANNAERT PIETER belongs. Expert number:X4328
Nederlands |
