Research team  Department of Human Genetics

Research team description:

Study of cell surface molecules in normal and abnormal Study of cell surface molecules in normal and abnormal morphogenesis, in genetically abnormal and malignant human and morphogenesis, in genetically abnormal and malignant human and animal model systems. Genetics of mental retardation. Molecular animal model systems. Genetics of mental retardation. Molecular diagnosis of genetic and malignant disease. diagnosis of genetic and malignant disease. Present and future changes of the human gene pool. Molecular Present and future changes of the human gene pool. Molecular neurobiology. Clinical genetics. Perception and attitudes of the neurobiology. Clinical genetics. Perception and attitudes of the population towards genetic testing and use of genetics. population towards genetic testing and use of genetics. Influence of environmental agents on somatic cells (cancer and Influence of environmental agents on somatic cells (cancer and leukemia) and on progeny; changes in the population as a result leukemia) and on progeny; changes in the population as a result of genetic services to the population, with particular emphasis of genetic services to the population, with particular emphasis on Belgium. Development of new technologies in somatic cell on Belgium. Development of new technologies in somatic cell genetics, chromosome analysis, gene identification, image genetics, chromosome analysis, gene identification, image analysis and processing in biological systems. Human genome analysis and processing in biological systems. Human genome analysis and project. Causes and consequences of twinning. analysis and project. Causes and consequences of twinning. Gene therapy. Gene therapy.
 

Functional characterization of non-synonymous variants in PC1/3 that confer risk of obesity in Europ...
Maintaining neurotransmission: Clathrin-mediated endocytosis and kiss-and-run.
A functional human genome project: integrated research of human congenital disorders.
Role of pink1, a Parkinson related gene, in mitochondria and synaptic activity.
Mitochondrial involvement in the regulation of neurotransmission in health and disease.  
Integrating Plag1 and PlagL2 in molecular signalling pathways controlling tumorgenesis and biologica...
Nanodomain targeting and localization of distinct gamma-secretase complexes versus APP.  &...
The genetic legacy of the contemporary Belgian population using the phylogographic approach.
In vitro and in vivo models for the study of activated tyrosine kinases in T-cell acute lymphoblasti...
The role of protein tyrosine kinase signaling in the pathogenesis of T-cell acute lymphoblastic leuk...
Contributing to a functional annotation of the human genome.
Signal transduction via protein tyrosine kinases and RAS: acqui- red genetic lesions in hypereosinop...
Identification of recurrent genetic aberrations in BCR-ABL1 negative myeloproliferative neoplasms th...
Molecular and functional characterization of MALT1- and AP12-MALT1-mediated NF-κB activation in...
Characterization and treatment of the cognitive defects in Spred1 knockout mice, and in patients wit...
Functional relevance of epigenetic changes in mental retardation.
Molecular determinants of axon-dendrite specification in relation to neuronal migration and mental r...
EUROGENTEST-NET (EUGT2): Harmonizing genetic testing across Europe.
Identifying Monosomy 1p36 syndrome as a ciliopathy through exploring the functional role of the ER-G...
ARF6-mediated endocytosis: the missing link to the gamma-secretase independent role of presenilin 1 ...
MEST-CT-2005-020589 EURON: European graduate school of neuroscience.
MEST-CT-2005-020013 NEURAD: Neurodegeneration in Alzheimer's disease - mechanisms, consequences ...
Role of protein tau in neurons and its modulation by kinases GSK-3 and cdk5 in normal and pathologic...
Synaptic mechanisms of memory loss: novel cell adhesion molecules as therapeutic targets.
Analysis of adaptations of cytoskeleton, dendritic spines and synaptic plasticity in relation to phy...
Tau-based Mabs and Vaccines: development and pre-clinical assessment of diagnostic and therapeutic p...
Evaluation of the proprotein convertase furin as a potential therapeutic target.
Cel-cel en cel-matrix interacties.
Unravelling the nuclear function of PDZ domain-phosphatidylinositol 4,5-biphosphate interaction in c...
EMBO Young investigator programme grant.
Mental retardation in human and fly: mRNA trafficking and controlled translation.
Molecular, biochemical and genetic studies of the autism in the context of the Fragile X Syndrome.&n...
Investigation of genomic copy number variations as possible cause of subfertility and (recurrent) mi...
Drosophila malanogaster as a genetic model organism to unravel the molecular mechanisms of neurodege...
Neurodegenerative disorders, neuroprotective mechanisms and the aging brain.
From gene networks to neural networks: an integrated computational-genetic approach.
Moleculaire biologie van tyrosyl-tRNA synthetase (YARS) mutaties geassocieerd met perifere neuropath...
Study of the role of lysosomal dysfunction and autophagy in neurodegenerative Drosophila mutants.
The role of LRP1 als modulator of the activity of (pro-)heparanase-1 in tumor growth and metastasis....
Novel causes of "Congenital Disorders of Glycosylation" (CDG): exploration of potential, new links t...
Investigation of a new tumor supressor gene causing an autosomal dominant condition resembling neuro...
Rare disease Portal - RD PORTAL. 
EUROGENE: the first pan-European learning service in the field of genetics.
Generation of a functional CFTR-mutatogram and search for rescuing mutations of F508del.
A functional human genome project: integrated research of human congenital disorders.
Prader-Willi Syndrome: a model linking gene expression, obesity and mental health.
Molecular pathogenesis of malignant tumours in Neurofibromatosis type 1 and identification of molecu...
Moleculaire pathogenese van neurofibromatosis type 1 en verwante aandoeningen.
Tyrosine phosphorylation: early switch and target in cancer development.
The dual role of LPR1 in generation and clearance of Aβ.
Chronic B-lymphocytic leukemia and other indolent B-lymphoproliferative disorders: towards improved ...
Multiparametric flow cytometric analysis of oncogenic signal transduction mechanisms in primary leuk...
Analysis of mitochondrial dysfunction in Parkinson disease.
Development of a diagnostic test for neonatal hypotonia caused by PREPL deficiency.   ...
Point mutations as a novel genetic mechanism for fragile X syndrome: structure-function in sights in...
The role of the rhomboid PARL  in neurodegenerative diseases.
The role of the ApoE receptor LRP1 in processes relevant for the development of the metabolic syndro...
Drosophila as a discovery platform for the identification of novel genetic modifiers and therapeutic...
Environmental cancer risk, mutrition and individual susceptibility.
Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals...
ER Quality Control in Cellular Sensing and Signaling: discovering new links and opportunities for di...
Regulation of developmental signalling and patterning by cell surface heparan sulfate proteoglycan-m...
An integrated approach to the unraveling of the pathogenesis of CNS and PNS neurodegenerative disord...
Mammalian heparanase as modulator of FGF-signalling and target in the control of tumor angiogenesis....
Molecular analysis of the gamma-Secretase complex.
The syntenin pathway, a novel target to counteract cancer progression.
Characterisation of a novel exosomal pathway, supported by syndecan-syntenin.   
Paracrine and transcriptional control of embryogenesis.
Glypican-supported mechanisms of morphogen movement and signaling.
In vivo function of telencephalin and presenilin 1 in hippocampal neurons: from trafficking and lyso...
FURINHIB: validation of furin as a therapeutic target in cancers with poor prognosis using novel inh...
Identification and characterisation of novel factors to induce axonal regeration after injury.
In vivo structure-function analysis of the atonal transcription factor.
Molecular mechanisms of tumor suppression by the atonal transcription factor.
The Spred Drosophila loss-of-function model.
Doctoral School Biomedical Sciences - Cancer programme.       
Is de GABA(A) receptor een therapeutische target voor behandeling van het fragiele X syndroom?
Computational biology of developmental gene regulation.
Decoding transcriptional networks regulating nervous system development in Drosophila.
TRP channels in the central nervous system of Drosophila.
The ER-quality control protein Rer1p is required for functional cilia - implications for zebrafish d...
Identification of recurrent genetic aberrations in myeloproliferative neoplasms using an integrated ...
Mechanisms underlying protein tau-mediated neurodegeneration: 
combining transgenic mouse mo...
Rer1: A new Notch in apical sorting and vesicular trafficking.
Deregulated signaling pathways in cancer: from genetic insights towards targeted therapy.
  
From genes to functional defects in hereditary and malignant diseases.
Endosomal and Exosomal Compartmentalization of Signalling Cascades: Relevance of the syntenin-syndec...
A functional human genome project: integrated research of human congenital disorders.
Identification of novel genes for autism and association with endophenotypes.
On the evolution of the regulatory genome.
Rare Disease Platform.
Regulation of ciliogenesis in neurodevelopment and de novo lipogenesis ubrafish as a model organism....
Short 3’UTRs of spermatozoal transcripts are required for preimplantation embryogenesis.
Control of neuropeptide secretion by the quality control ER-Golgi recept in Drosophila.
Discovery and prioritization of gene regulatory modules driving oncogenesis.
Elucidating causative genes and pathogenetic mechanisms in cancer: a systems biology approach. ...
Investigation of oncogenic cooperation and self-renewal capacity in T-cell acute lymphoblastic leuke...
The involvement of 'Presenilin associated rhomboid-like (PARL)' in neurodegeneration.
Mechanism of neuronal survival during aging: relationship to performance.

Analyzing of TGF-B signaling pathway in desmoid tumors
Mutations of the Wiskott-Aldrich syncrome gene and the origin of familial and de novo myeloid leukem...
Identification of gamma-secretase activity regulators using Drosophila melanogaster
Genetic screens to characterize novel genes in neuronal communication
Circulating cell-free fetal DNA in maternal plasma: New approaches for non-invasive prenatal diagnos...
The role of LRP1 in the development of atherosclerosis.
Molecular analysis of T-cell acute lymphoblastic leukemia
TPARL/dysostin: a novel inborn error of glycosylation, possibly due to a pH defect in the Golgi comp...
Loss of function of Spred in the Drosophila model for Legius syndrome
Fusion en fission of mitochondria in synaptic neuropathology
Identification of novel X-linked genes implicated in neuronal communication.
Genome wide screens and in depth analyses of neurological disease related genes that affect the mech...
The molecular chrarterisation of tumors in patients with neurofibromatosis type 1.
Identification of new drug targets for cancer treatment using forward genetic screens
The role of PREPL in hypotonia-cystinuria syndrome
Modelling amyotropic lateral sclerosis in flies and fish
Role of Cop1 in Development of Mouse Melanoma
Functional role of presenilin 1 and 2 in cell migration and neurite outgrowth.
Een nieuw RabGTPase activerend proteïne betrokken in neuronale communicatie.
Identification and functional characterization of Parkinson related genes in Drosophila
Wnt signalling and aggression in Drosophila melanogaster from neurogenetics to candidate-drugtargets...
Neurodegeneration in Alzheimer's disease - mechanisms, consequences and therapy
Analysis of contributions of GSK3 isozymes and cel-adhesion molecules (CAM) to synaptic plasicity
The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzhe...
Tau Mabs and Vaccines: pre-clinical assessment in transgenic mouse models for Tauopathy & A...
Moleculaire en functionele karakterisatie van een nieuw neuro-cardio-faciaal-cutaan syndroom.
High resolution molecular karyotyping of single cell to unravel mechanisms causing genomic disorders...
LRP1 as modulator of the activity of heparanase-1: impact on tumor growthand metastasis.
The role of PINK1 in Parkinson's disease and mitochondria function.
Detection of novel cytogenetic aberrations, cytogenetic patterns and genomic aberrations in chronic ...
Study of biological function of Amyloid Precursor Protein in nervous system
Analysis of the regulation of the protease activity of ADAM10 in neurons in aging and disease
Characterization of the function and structure of the gamma secretase
Functional Analysis in Drosophila of human NEUROBEACHIN, a candidate gene for autism, and its Drosop...
Quantitative and qualitative quality assurance in genetics
role of VEGF and VEGF receptors in the pathogenesis of leukemia
Superparamagnetic nanoparticles for targeted subcellular proteomics and identification of novel biom...
The syntenin pathway in cell polarity
Causal genomic duplications in patients with mental retardation: role of overexpression of genes on ...
Mammalian heparanase as decoder of signals: functional analyis and possible targets for tumor therap...
Oncogenesis of tumors in neurofibromatosis type 1 and related disorders.
Molecular genetics of hematological malignancies
Characterization of aging genes in Drosophila nervous system
RMCE in the LRP1 gene: functional analysis of knock-in mutants in relation to disease Alzheime.
Copy number variations as cause of infertility and embryonic lethality
Genetics of Brain Malformations: Towards the Identification of New Genes Involved in Brain Develo...
Function of PDZ domain-PIP2 interactions in cell signaling
Exploring the biology of heparanase-1 en heparanase-2 in zebrafish: towards novel insights into the ...
Genetic identification of novel drug targets for tauopathies in D. Melanogaster
Identification and characterisation of the cell surface receptor(s) of sAPPalpha
Establishment of Axon/Dentrite Fate in CNS neurons
The role of cell cycle proteins in post-differentiated neuron physiology
Optimisation and use of a chromosomal vector for the study of SOX3 and MECP2 gene dosage effects in ...
The identification and characterisation of genes involved in human cognition.
Generation and characterization of the miRNA-29 family knockout mouse models
The role of LRRK2 in Parkinson's Disease.
Celbiologische analyse van defecten in ER-Golgi transport en in Golgi compartimentalisatie in aangeb...
Identification and functional characterisation of candidate genes for autism.
The role of cell adhesion and axon guidance molecules in Drosophila brain development
Characterization of the FMRP-ncRNA complex/es in physiological and pathological conditions
Structural and functional characterization of the mulitple isoforms of the FMR1 gene in physiologica...
Characterization of the FMRP functions in cell migration and cytoskeleton remodelling
The mechanistic role of Fragile X Mental Retardation protein in altering synaptic plasticity and neu...
TRP channels in the central nervous system of Drosophila.
From Gene Networks to Neural networks: An integrated Computational-Genetic-Behavioral Approach.
Computational modelling of genetic control of neural circuit development.
Role of APPL in neural development.
The role of protein phosphatases in double strand break repair
Computational analysis of perturbed transcriptional regulation in cancer.
Mutante proteïne tyrosine kinasegenen in leukemie en lymfoom.
Structure-Function Analysis of the Fragile X Mental Retardation Protein (FMRP)
Identification of novel genes causing microcephaly using genomic approaches.
MYB as target for therapy in T-cell acute lymphoblastic leukemia.
The use of induced pluripotent stem cells in the study of patient-specific disease models for neurod...
Identification of protein tyrosine kinases as therapeutical targets in cancer using a RNAi-screen.
Pathofysiology of bone tumors and congenital pseudoarthrosis in neurofibromatosis type 1
Opsporing nieuwe ziekteveroorzakende genen bij erfelijke mentale retardatie
Exploring the endocytic route of ICAM-5 in hippocampal neurons - a strategy to reveal the gamma-secr...
The role of bHLH transcription factors in neuronal differentiation using Drosophila as a model syste...
Identification of novel genetic pathways involved in axon regeneration post injury
BACE1-Physiological relevance of candidate substrates and inhibition of AB generation via the B-secr...
Ontrafelen van de genetische factoren die de Wolf-Hirschhorn syndroom fenotypes veroorzaken.
Characterization of the regulated secretory pathway in neurons of a mouse model for autism.
FAM120C as new candidate gene for Autism Spectrum Disorders.
Identification of candidate genes for autosomal forms of mental retardation by high throughput posit...
Functional annotation of the human genome - characterization of regions and genes implemented in eye...
Evaluation of candidate alpha-secretases of the ADAM family for their role in pathogenesis and thera...
Identification of gene(s) involved in limb development and skeletal differentiation.
The role of Nxf7 in dendritic RNA and its function in memory
A quantitative-genetic, neuroanatomical and molecular analysis of aggression, a complex behavior in ...
Neuronal polarity: molecular dissection of centrosome-regulated axon outgrowth
Parkinson's disease: identification and validation of PINK1 substrates.
Creatie van een biomimetische interface voor sturing van neuronale groei op microchips: een interfac...
Mutations in the Amiloride Sensetive Epithelial Sodium Channel in CystiFibrosis.
Novel genetic mechanisms and congenital heart defects.
Deciphering the tumor suppression mechanism of the Atonal transcription factor
In vivo analysis of the gamma-secretasecomplex - contribution of the Aph-1-genes.
Towards a better understanding of Di-CMTC, a contribution from Drosophila
The role of BMP-Smads pathway in vessel development
Characterization of the non-catalytic function of the putative oligopeptidase PREPL and its function...
Characterisation and molecular dissection of the embryonal chromosomal instability in human and anim...
From nanotechnology to endosomal proteomics: a global approach to study endosomal (dys)function.
Molecular mechanisms of synaptic vesicle rejuvenation: Skywalker and epilepsy
Drosophila models for TDP-43 and FUS proteinopathy, new therapeutic targets for neurodegeneration
The development of single-cell haplotyping as a generic method for preimplantation genetic diagnosis...
Genome wide CNV detection in blastomeres of pre-implantation embryos using array CGH
Glycogen synthase kinase-3 in brain physiology and pathology
Fosfoinositides in gezonde en zieke neuronen.
The role of furin in beta cell proliferation.
Specific study of the molecular mechanisms of Spinal Muscular Atrophy and axonal mRNA transport
Study of pro- and anti apoptotic pathways in the neuronal senescence
Investigation of the gamma-secretase heterogenety
The study of mRNA metabolism and synaptic plasticity in Fragile X syndrome
Development of monoclonal antibody/nanobody for β-secretase (BACE1) as potential therapy f...
Identifying functional transcriptional targets by next-generation sequencing.
Genetic studies of intellectual disability in Central Africa
Study of the molecular mechanisms of AMPK function in the central nervous system of D. Melanogaster....
Next generation sequencing and congenital heart defects
Single cell genomics
Identification and biological relevance of stubstrates of leucine-rich repeat kinase 2 (LRRK2)
Identification of oncogenic mutations in large patients groups by means of next-generation sequencin...
A systemic search for novel congenital disorders of Glycosylation type 1 (CDG-I), with a comprehensi...
Fragile X syndrome: regulation of activity-dependent mRNA localization and translation at synapses.
Analysis of the gamma-secretase complex using monoclonal antibodies.
Identification and characterization of candidate disease-genes for motor neuron diseases.
Mechanisms of physiologic regulation of furin action and their impact on the immune system related t...
Evolution of the regulatory genome in Drosophila.
The Role of LRP1 in Tumor Growth and Metastasis.
Identification of the neuronal function of epsilon-sarcoglycan
The role of the interaction of the PDZ protein syntenin 2 with nuclear lipids and nucleic acids.
Search for ncRNAs that contribute to oncogene-induced senescence.
Molecular correlation between Alzheimer disease and Fragile X syndrome.
Study on the contribution of epigenetic modifications in X-linked mental retardation.
Gene identification in female patients with intellectual disability and skewed X-inactivation.
LRRK2 signalling pathways: validation and evaluation of the physiologic relevance of candidate subst...
Understanding embryonic chromosome instability and the origins of structural genetic variation by ge...

Expertises of research team  Department of Human Genetics :

Expertise VAN LEUVEN FREDDY
Transgenic mice Neurodegeneration Alzheimer's disease
Expertise VAN LEUVEN FREDDY
Transgenics : - overexpression - homologous recombination Protein sequencing Gene structure Alzheime...
Expertise VAN DE VEN WILLEM
Molecular Genetics, Molecular Biology, Molecular Oncology, Animal Cell Biotechnology
Expertise DECORTE RONNY
Human population genetics, forensic DNA-analysis, genetic identification of human biological sample...
Expertise DEQUEKER ELISABETH
- Education on quality systems and management - Organisation of external quality assessment schemes ...
Expertise VERMEESCH JORIS
Fluorescent in situ hybridisation enables the localisation and quanitification of loci in the genome...
Expertise CASSIMAN JEAN JACQUES
DNA polymorphisms for identification of biological samples for paternity studies
Expertise DAVID GUIDO
Heparan sulfate proteoglycans in cell-to-cell signaling.
Expertise DE STROOPER BART
Information/analysis on/of current research in Alzheimer's disease.
Expertise FRIJNS JEAN PIERRE
The Dept. of Clinical Genetics of the Center for Human Genetics is an international authority in: 1....
Expertise MATTHIJS GERT
Genetic diseases: molecular diagnosis.
Expertise ROEBROEK ANTONIUS
Designing strategies for the generation of (conditional) knock-out and knock-in mice using embryonic...
Expertise AERTS STEIN

• Bioinformatics services
• Information on bioinformatics software
• Analysis of n...
  Expertise ANNAERT WILLEM
  1. In de loop der jaren werd een grondige expertise opgebouwd in het gebruik van confocale laser sca...
  Expertise ANNAERT WILLEM
  Het ter beschikking stellen van mijn expertise in het gebruik van doorgedreven technieken van subcel...
  Expertise VOET THIERRY
  Single-cell genome analysis by next-generation sequencing
  
  

Research team number: 50000622