Research team  Laboratory for Medicinal Chemistry

Research team description:

- Development of nucleoside derivatives with antiviral (AIDS chemotherapy) and antitumoral activity. - Development of oligonucleotides for chemotherapeutic and diagnostic purposes. - Development of oligopeptides as enzyme inhibitors (combinatory libraries).
 

Cyclohexenyl nucleic acids for siRNA application and the construction of an artificial genetic syste...
Centrum voor Drug Design and Discovery in de K.U.Leuven.
Proteins: Interactions involved in folding, function and supramolecular assemblages.
Structural NMR investigations of the type 1 signal peptidase of Staphylococcus epidermidis and scree...
Biomolecular structural studies of protein-nucleic acids interactions for siRNA application.
Molecular modeling, synthesis and biological evaluation of human amino-acyltRNA synthetase inhibitor...
Nucleotides, nucleic acids and their analogues as tools or targets for inhibitor design.  ...
Synthesis of pyrophosphate analogues with a phosphonate function.
"Capturing the CAP4": a new class of diagnostics fro Trypanosomatidae infections.
New and improved techniques for drug development.
Drug development based on Thymidylate Synthase (TS).
Overcoming the hERG affinity of a novel class of immunosuppressive thiazolo[5,4-d]pyrimidine...
<p>Synthesis of novel and drug-like compound libraries for screening acrroad range of therapeu...
Structure determination of Schizosaccharomyces Pombe tRNAimet by NMR spectroscopy. 
A drug discovery platform focusing on fragment-based drug design and aptamers.

Synthesis of oxopiperidinc oligomers
Improving the intestinal permeability of drugs with a prodrug-strategy
Computational design, synthesis and experimental evaluation of new ATPase inhibitors of DNA Gyrase a...
A Trojan horse strategy for antimicrobial therapy
Lipids as template for oligomerization of nucleotides.
5'-modified nucleoside analogues as RNA polymerase inhibitors/substrates
Structural and biophysiocal studies of biologically relevant RNAs and their potentiol interactions
Deoxyxylose nucleic acids as othonal information system in vitro and in vivo
Development of RNase H inhibitors as new anti-HIV therapy.
Synthesis of potential inhibitors in "mycolocterium tuberculosis"
Development of nulceotide conjugates for the active uptake of nucleotides in bacteria
Thymidylate synthase X as a target for new antibiotics
Synthesis and stability study of base modified nucleoside phosphoramidate analogues and evaluation o...
Synthesis and evaluation of microcin C analogs as aminoacyl-tRNA synthetase inhibitors.
Synthesis of new phosphonate nucleïden as potential antivirals
Alternative leaving groups for pyrophosphate in the polymerization of nucleotides to DNA/RNA.
Desgin and synthesis of modified heterocycles as potential antiviral agents
Design and synthesis of new compound libraries targeting kinases
Synthesis and biological evaluation of inhibitors of the  of UvrD helicaseMycobacterium tubercu...
Vectors for the active uptake of nucleotides in bacterial cells - A model for the development of new...
A rational drug design for the generation of Thy-X inhibitors for the teratment of tuberculosis
The generation of HNA - based aptamer against betasecretase BACE-1 for Alzheimer Disease treatment

Expertises of research team  Laboratory for Medicinal Chemistry :

Expertise HERDEWYN PIET
Elucidation of molecular structures with NMR and MS
Expertise HERDEWYN PIET
Synthesis and development of nucleosides and oligo nucleotides with potential therapeutic properties...
Expertise HERDEWYN PIET
Development of peptide libraries.
Expertise BUSSON ROGER
Structural analysis of antibiotics, antivirals, or anticancer agents by 1H or 13C NMR spectroscopy.
Expertise HERDEWYN PIET
Synthesis of isotope labelled RNA.
Expertise ROZENSKI JOZEF
- Mass spectrometry of bio molecules - Oligonucleotide sequencing and mapping of post-transcriptiona...
Expertise HERDEWYN PIET
Development of biological active compounds.
Expertise VAN AERSCHOT ARTHUR
- Chemical DNA synthesis techniques.
- Synthesis of nucleoside and nucleotide analogues.
- Oli...
Expertise LESCRINIER EVELINE
NMR guided fragment based drug design
Expertise LESCRINIER EVELINE
monitoring of enzym activity
Expertise LESCRINIER EVELINE
small molecule identification
Expertise LESCRINIER EVELINE
Biomolecular structure determination
Expertise LESCRINIER EVELINE
ligand binding studies

Research team number: 50000720