Publications

2011

Alzheimer’s Disease

• Zhou L., Brouwers N., Benilova I., Vandersteen A., Mercken M., Van Laere K., Van Damme P., Demedts D., Van Leuven F., Sleegers K., Broersen K., Van Broeckhoven C., Vandenberghe R., De Strooper B. (2011) Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. EMBO Molecular Medicine, in press.
• Brouwers N., Van Cauwenberghe C., Engelborghs S., Lambert J.C., Bettens K., Le Bastard N., Pasquier F., Montoya A.G., Peeters K., Mattheijssens M., Vandenberghe R., De Deyn P.P., Cruts M., Amouyel P., Sleegers K., Van Broeckhoven C. (2011) Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Molecular Psychiatry, in press.
• Thomas B.A., Erlandsson K., Modat M., Thurfjell L., Vandenberghe R., Ourselin S., Hutton B.F. (2011) The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, in press.
• Zhou L., Chavez-Gutierrez L., Bockstael K., Sannerud R., Annaert W., May P.C., Karran E., De Strooper B. (2011) Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. Journal of Biological Chemistry [Epub ahead of print].
• Bateman R.J., Aisen P.S., De Strooper B., Fox N.C., Lemere C.A., Ringman J.M., Salloway S., Sperling R.A., Windisch M., Xiong C. (2011) Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimer's Research & Therapy 2(6): 35.
• Weber S., Niessen M.T., Prox J., Lüllmann-Rauch R., Schmitz A., Schwanbeck R., Blobel C.P., Jorissen E., De Strooper B., Niessen C.M., Saftig P. (2011) The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development 138(3): 495-505.
• Thathiah A., De Strooper B. (2011) The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nature Reviews Neuroscience 12(2): 73-87.
• Bammens L., Chavez-Gutierrez L., Tolia A., Zwijsen A., De Strooper B. (2011) Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. Journal of  Biological Chemistry [Epub ahead of print]. 
• Thomas B.A., Erlandsson K., Modat M., Thurfjell L., Vandenberghe R., Ourselin S., Hutton B.F. (2011) The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging [Epub ahead of print].
• Dhollander I., Nelissen N., Van Laere K., Peeters D., Demaerel P., Van Paesschen W., Thijs V., Vandenberghe R. (2011) In vivo amyloid imaging in cortical superficial siderosis. Journal of Neurology, Neurosurgery & Psychiatry 82(4): 469-71.

Parkinson's Disease

• Daniëls V., Vancraenenbroeck R., Law B.M.H., Greggio E., Lobbestael E., Gao F., De Maeyer M., Cookson M.R., Harvey K., Baekelandt V., Taymans J.-M. (2011) Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. Journal of Neurochemistry 116(2): 304-15.
• Van der Perren A., Toelen J., Coun F., Van den Haute C., Heeman B., Carlon M., Reumers V., Vandenberghe L.H., Wilson J.M., Debyser Z., Baekelandt V. (2011) Efficient transduction of dopaminergic neurons in rat substantia nigra by different adeno-associated viral vector serotypes. Gene Therapy Feb 17 2011. [Epub ahead of print]
• Heeman B., Van den Haute C., Aelvoet S.-A., Valsecchi F., Rodenburg R., Reumers V., Debyser Z., Callewaert G., Koopman W.J.H., Willems P.H.G.M., Baekelandt V. (2011) Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. Journal of Cell Science 124(7):1115-25.
• Daniëls V., Baekelandt V., Taymans J.-M. (2011) On the road to lrrk2 signalling evidence from cellular and in vivo studies. Neurosignals, in press.
• Vandeputte C., Evens N., Toelen J., Deroose C., Bosier B., Ibrahimi A., Van der Perren A., Gijsbers R., Janssen P., Lambert D.M., Verbruggen A., Debyser Z., Bormans G., Baekelandt V., Van Laere K. (2011) A type 2 cannabinoid receptor based PET reporter gene system for the brain. Journal of Nuclear Medicine, in press.
• Verhaar R., Jongenelen C.A., Gerard M., Baekelandt V., Van Dam A.-M., Wilhelmus M., Drukarch B. (2011) Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's Disease. Neurochemistry International, in press.
• Van Laere K., Casteels C., Lunskens S., Goffin K., Grachev I.D., Bormans G., Vandenberghe W. (2011) Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo. Neurobiology of Aging [Epub ahead of print].
• Gerard M., Deleersnijder A., Demeulemeester J., Debyser Z. and Baekelandt V. Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration. Molecular Neurobiology, in press
• Deleersnijder A., Desender L., Munck S., Pottel H., Buée L., Debyser Z., Baekelandt V. and Gerard M. Comparative analysis of different peptidyl-prolylisomerases reveals FK506-binding protein 12 as the most potent enhancer of α-synuclein aggregation. Journal of  Biological Chemistry, in press

Motor neuron disease

• Schrooten M., Smetcoren C., Robberecht W., Van Damme P. (2011) Benefit of the awaji diagnostic algorithm for amyotrophic lateral sclerosis: A prospective study. Annals of Neurology [Epub ahead of print].
• van der Graaff M.M., Sage C.A., Caan M.W., Akkerman E.M., Lavini C., Majoie C.B., Nederveen A.J., Zwinderman A.H., Vos F., Brugman F., van den Berg L.H., de Rijk M.C., van Doorn P.A., Van Hecke W., Peeters R.R., Robberecht W., Sunaert S., de Visser M. (2011) Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study. Brain 134(Pt 4): 1211-28.
• Philips T., Robberecht W. (2011) Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. The Lancet Neurology 10(3): 253-63.
• Dhondt J., Peeraer E., Verheyen A., Nuydens R., Buysschaert I., Poesen K., Van Geyte K., Beerens M., Shibuya M., Haigh J.J., Meert T., Carmeliet P., Lambrechts D. (2011) Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB Journal 25(5): 1461-73.

Frontotemporal degeneration

• van der Zee J., Van Langenhove T., Kleinberger G., Sleegers K., Engelborghs S., Vandenberghe R., Santens P., Van den Broeck M., Joris G., Brys J., Mattheijssens M., Peeters K., Cras P., De Deyn P.P., Cruts M., Van Broeckhoven C. (2011) TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort. Brain 134(Pt 3): 808-15.

• Gorno-Tempini M.L., Hillis A.E., Weintraub S., Kertesz A., Mendez M., Cappa S.F., Ogar J.M., Rohrer J.D., Black S., Boeve B.F., Manes F., Dronkers N.F., Vandenberghe R., Rascovsky K., Patterson K., Miller B.L., Knopman D.S., Hodges J.R., Mesulam M.M., Grossman M. (2011) Classification of primary progressive aphasia and its variants. Neurology 76 (2011): 1006-14.

Other Disorders

• Gillebert C.R., Mantini D., Thijs V., Sunaert S., Dupont P., Vandenberghe R. (2011) Lesion evidence for the critical role of the intraparietal sulcus in spatial attention. Brain, in press.
• Geeraerts B., Van Oudenhove L., Dupont P., Vanderghinste D., Bormans G., Van Laere K., Tack J. (2011) Different regional brain activity during physiological gastric distention compared to balloon distention: a H215O-PET study. Neurogastroenterology and Motility, in press.
• Demaerel P., Van Dessel W., Van Paesschen W., Vandenberghe R., Van Laere K., Linn J. (2011) Autoimmune-mediated encephalitis. Neuroradiology [Epub ahead of print].
• Kovacs G.G., Seguin J., Quadrio I., Höftberger R., Kapás I., Streichenberger N., Biacabe A.G., Meyronet D., Sciot R., Vandenberghe R., Majtenyi K., László L., Ströbel T., Budka H., Perret-Liaudet A. (2011) Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy. Acta Neuropathologica 121(1): 39-57.
• Stroobants S., Gerlach D., Matthes F., Hartmann D., Fogh J., Gieselmann V., D'Hooge R., Matzner U. (2011) Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Human Molecular Genetics [Epub ahead of print].
• Faldini E., Stroobants S., Lüllmann-Rauch R., Eckhardt M., Gieselmann V., Balschun D., D'Hooge R. (2011) Telencephalic histopathology and changes in behavioural and neural plasticity in a murine model for metachromatic leukodystrophy. Behavioural Brain Research [Epub ahead of print].
• Damme M., Stroobants S., Walkley S.U., Lüllmann-Rauch R., D'Hooge R., Fogh J., Saftig P., Lübke T., Blanz J. (2011) Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis. Journal of Neuropathology & Experimental Neurology 70(1): 83-94.
• Caeyenberghs K., Leemans A., Coxon J., Leunissen I., Drijkoningen D., Geurts M., Gooijers J., Michiels K., Sunaert S., Swinnen S.P. (2011) Bimanual coordination and corpus callosum microstructure in young adults with traumatic brain injury: A diffusion tensor imaging study. Journal of Neurotrauma [Epub ahead of print].
• Caeyenberghs K., Leemans A., Geurts M., Vander Linden C., Smits-Engelsman B.C., Sunaert S., Swinnen S.P. (2011) Correlations between white matter integrity and motor function in traumatic brain injury patients. Neurorehabilitation and Neural Repair [Epub ahead of print].
• Lemmens R., Piessens F., Demaerel P., Robberecht W. (2011) Unilateral white matter involvement in Krabbe disease. Archives of Neurology 68(1): 130-1.
• Goris A., Fockaert N., Cosemans L., Clysters K., Nagels G., Boonen S., Thijs V., Robberecht W., Dubois B. (2011) TNFRSF1A coding variants in multiple sclerosis. Journal of Neuroimmunology Jun;235(1-2):110-2.
• Comi G., Cohen J.A., Arnold D.L., Wynn D., Filippi M. (2011) Phase III dose-comparison study of glatiramer acetate for multiple sclerosis. Annals of Neurology 69(1): 75-82.
• International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Boneschi FM, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox MB, Cozen W, Cree BA, Cross AH, Cusi D, Daly MJ, Davis E, de Bakker PI, Debouverie M, D'hooghe MB, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant SF, Guerini FR, Hakonarson H, Hall P, Hamsten A, Hartung HP, Heard RN, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode AG, Kilpatrick TJ, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott JS, Leone MA, Leppä V, Liljedahl U, Bomfim IL, Lincoln RR, Link J, Liu J, Lorentzen AR, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley JL, Mentch F, Mero IL, Mihalova T, Montalban X, Mottershead J, Myhr KM, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach HL, Ramsay PP, Reunanen M, Reynolds R, Rioux JD, Rodegher M, Roesner S, Rubio JP, Rückert IM, Salvetti M, Salvi E, Santaniello A, Schaefer CA, Schreiber S, Schulze C, Scott RJ, Sellebjerg F, Selmaj KW, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman PM, Smestad C, Sørensen PS, Søndergaard HB, Stankovich J, Strange RC, Sulonen AM, Sundqvist E, Syvänen AC, Taddeo F, Taylor B, Blackwell JM, Tienari P, Bramon E, Tourbah A, Brown MA, Tronczynska E, Casas JP, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus HS, Wang K, Mathew CG, Wason J, Palmer CN, Wichmann HE, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath RC, Yaouanq J, Viswanathan AC, Zhang H, Wood NW, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg JR, Pericak-Vance MA, Haines JL, Olsson T, Hillert J, Ivinson AJ, De Jager PL, Peltonen L, Stewart GJ, Hafler DA, Hauser SL, McVean G, Donnelly P, Compston A. (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. Aug 10;476(7359):214-9. doi: 10.1038/nature10251.
• International Multiple Sclerosis Genetics Consortium. (2011) The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. PLoS One. Apr 28;6(4):e18813.

Basic Neurosciences

• Lunskens S, Lammertijn L, Deeren D, Bergmans B, Maertens J, Vandenberghe R. (2011) Intracranial hypertension following intrathecal administration of liposomal cytarabine. Journal of Neurology 258 (2011): 162-163.
• Sydow A., Van der Jeugd A., Zheng F., Ahmed T., Balschun D., Petrova O., Drexler D., Zhou L., Rune G., Mandelkow E., D'Hooge R., Alzheimer C., Mandelkow E.M. (2011) Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. The Journal of Neuroscience 31(7): 2511-25.
• Van der Jeugd A., Ahmed T., Burnouf S., Belarbi K., Hamdame M., Grosjean M.E., Humez  S., Balschun D., Blum D., Buée L., D'Hooge R. (2011) Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission. Neurobiology of Learning and Memory 95(3): 296-304.
• Trovò L., Van Veldhoven P.P., Martín M.G., Dotti C.G. (2011) Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis. Journal of Cell Science 124(Pt 8): 1308-15.
• Sodero A.O., Trovò L., Iannilli F., Van Veldhoven P., Dotti C.G., Martin M.G. (2011) Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging. Journal of Neurochemistry 116(5): 747-55.
• Martin M.G., Trovò L., Perga S., Sadowska A., Rasola A., Chiara F., Dotti C.G. (2011) Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons. Neurobiology of Aging 32(5): 933-43.
• Uytterhoeven V., Kuenen S., Kasprowicz J., Miskiewicz K., Verstreken P. (2011) Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. Cell 145(1): 117-32.
• Naert A., Callaerts-Vegh Z., Moechars D., Meert T., D'Hooge R. (2011) Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry [Epub ahead of print].
• Naert A., Callaerts-Vegh Z., D'Hooge R. (2011) Nocturnal hyperactivity, increased social novelty preference and delayed extinction of fear responses in post-weaning socially isolated mice. Brain Research Bulletin [Epub ahead of print].
• Piccart E., Gantois I., Laeremans A., de Hoogt R., Meert T., Vanhoof G., Arckens L., D'Hooge R. (2011) Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution. Neurobiology of Learning and Memory 95(3): 260-9.
• Verhoef B.E., Vogels R., Janssen P. (2011) Synchronization between the end-stages of the dorsal and the ventral visual stream. Journal of Neurophysiology [Epub ahead of print].
• De Ridder D., Vanneste S., Kovacs S., Sunaert S., Dom G. (2011) Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: An fMRI and LORETA EEG study. Neuroscience Letters 496(1): 5-10.
• De Ridder D., Vanneste S., Kovacs S., Sunaert S., Menovsky T., van de Heyning P., Moller A. (2011) Transcranial magnetic stimulation and extradural electrodes implanted on secondary auditory cortex for tinnitus suppression. Journal of Neurosurgery 114(4): 903-11.
• De Ridder D., van der Loo E., Vanneste S., Gais S., Plazier M., Kovacs S., Sunaert S., Menovsky T., van de Heyning P. (2011) Theta-gamma dysrhythmia and auditory phantom perception. Journal of Neurosurgery 114(4): 912-21.
• Goble D.J., Coxon J.P., Van Impe A., Geurts M., Van Hecke W., Sunaert S., Wenderoth N., Swinnen S.P. (2011) The neural basis of central proprioceptive processing in older versus younger adults: An important sensory role for right putamen. Human Brain Mapping [Epub ahead of print].
• Van Hecke W., Leemans A., Sage C.A., Emsell L., Veraart J., Sijbers J., Sunaert S., Parizel P.M. (2011) The effect of template selection on diffusion tensor voxel-based analysis results. Neuroimage 55(2): 566-73.

2010

Alzheimer’s Disease

• Lau P., De Strooper B. (2010) Dysregulated microRNAs in neurodegenerative disorders. Seminars in Cell and Developmental Biology 21(7): 768-73.
• Bergmans B.A., Shariati S.A., Habets R.L., Verstreken P., Schoonjans L., Müller U., Dotti C.G., De Strooper B. (2010) Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally In Vitro and In Vivo: Lack of Evidence for a Cell Autonomous Role of APP in Neuronal Differentiation. Stem Cells 28(3): 399-406.
• Bergmans B.A. and De Strooper B. (2010) γ-secretases: from cell biology to therapeutic strategies. (Review) Lancet Neurology 9: 215-226.
• De Strooper B., Vassar R., Golde T. (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews Neurology 6: 99-107.
• Jorissen E., Prox J., Bernreuther C., Weber S., Schwanbeck R., Serneels L., Snellinx A., Craessaerts K., Thathiah A., Tesseur I., Bartsch U., Weskamp G., Blobel C.P., Glatzel M., De Strooper B., Saftig P. (2010) The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. Journal of Neuroscience 30(14): 4833-44.
• De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiological Reviews 90(2): 465-94.
• Espuny-Camacho I., Dominguez D., Merchiers P., Van Rompaey L., Selkoe D., De Strooper B. (2010) Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease 20(4): 1119-32.
• Morais V.A., De Strooper B. (2010) Mitochondria Dysfunction and Neurodegenerative Disorders: Cause or Consequence. Journal of Alzheimer's Disease 20 Suppl 2: S255-63 (Review).
• Zhang H., Sun S., Herreman A., De Strooper B., Bezprozvanny I. (2010) Role of Presenilins in Neuronal Calcium Homeostasis. Journal of Neuroscience 30(25): 8566-8580.
• Annaert W. and De Strooper B. (2010) Alzheimer's disease neurons fail the acid test. Cell 141(7): 1112-4.
• De Strooper B. and Annaert W. (2010) Novel research horizons for Presenilins and gamma-secretases in cell biology and disease. Annual Review of Cell and Developmental Biology 26: 25.1-25.26. (Review).
• Hébert S.S., Papadopoulou A.S., Smith P., Galas M.C., Planel E., Silahtaroglu A.N., Sergeant N., Buée L., De Strooper B. (2010) Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Human Molecular Genetics 19(20): 3959-69.
• Benilova I, De Strooper B. (2010) Prion protein in Alzheimer's pathogenesis: a hot and controversial issue. EMBO Molecular Medicine 2(8): 289-90.
• Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B. (2010) Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO Journal 29(19): 3408-20.
• Jorissen E., De Strooper B. (2010) Gamma-secretase and the intramembrane proteolysis of Notch. Current Topics in Developmental Biology 92: 201-30.
• Vandenberghe R., Van Laere K., Ivanoiu A., Salmon E., Bastin C., Triau E., Hasselbalch S., Law I., Andersen A., Korner A., Minthon L., Garraux G., Nelissen N., Bormans G., Buckley C., Owenius R., Thurfjell L., Farrar G., Brooks D.J. (2010) ¹⁸F-flutemetamol amyloid imaging in Alzheimer's disease and mild cognitive impairment: a phase 2 trial. Annals of Neurology 68(3): 319-329.

Parkinson's Disease

• Casteels C., Lauwers E., Baitar A., Bormans G., Baekelandt V., Van Laere K. (2010) In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease. Brain Research 1316:153-62.
• Gerard M., Deleersnijder A., Daniëls V., Schreurs S., Munck S., Reumers V., Pottel H., Engelborghs Y., Van den Haute C., Taymans J.-M., Debyser Z. and Baekelandt V. (2010) Inhibition of FK506 Binding Proteins reduces alpha-synuclein aggregation and Parkinson’s disease-like pathology. Journal of Neuroscience 30: 2454-2463.
• Van Camp N., Vreys R., Van Laere K., Lauwers E., Beque D., Verhoye M., Casteels C., Verbruggen A., Debyser Z., Mortelmans L., Sijbers J., Nuyts J., Baekelandt V., Van der Linden A. (2010) Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with muSPECT and quantitative MRI. MAGMA 23(2): 65-75.
• Vandeputte C., Taymans J.-M., Casteels C., Coun F., Van Laere K., Baekelandt V. (2010) Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience 11(1): 92.
• Meuvis J., Gerard M., Desender L., Baekelandt V., Engelborghs Y. (2010) The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region. Biochemistry 49(43): 9345-52.
• Van Laere K., Cleerinckx K., Dhont E., de Groot T., Vandenberghe W. (2010) Combined striatal binding and cerebral influx analysis of dynamic 11C-Raclopride PET improves early differentiation between multiple-system atrophy and Parkinson’s Disease. Journal of Nuclear Medicine 51(4): 588-595.

Motor neuron disease

• Shatunov A., Mok K., Newhouse S., Weale M.E., Smith B., Vance C., Johnson L., Veldink J.H., van Es M.A., van den Berg L.H., Robberecht W., Van Damme P., Hardiman O., Farmer A.E., Lewis C.M., Butler A.W., Abel O., Andersen P.M., Fogh I., Silani V., ChiÒ A., Traynor B.J., Melki J., Meininger V., Landers J.E., McGuffi n P., Glass J.D., Pall H., Leigh P.N., Hardy J., Brown Jr R.H., Powell J.F., Orrell R.W., Morrison K.E., Shaw P.J., Shaw C.E. and Al-Chalabi A. (2010) Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. Lancet Neurology 10: 986-94.
• Blauw H.M., Al-Chalabi A., Andersen P.M., van Vught P.W.J., Diekstra F.P., van Es M.A., Saris C.G.J., Groen E.J.N.,van Rheenen W., Koppers M., van’t Slot R., Strengman E., Estrada K., Rivadeneira F., Hofman A., Uitterlinden A.G., Kiemeney L.A., Vermeulen S.H.M., Birve A., Waibel S., Meyer T., Cronin S., McLaughlin R.L., Hardiman O., Sapp P.C., Tobin M.D., Wain L.V., Tomik B., Slowik A., Lemmens R., Rujescu D., Schulte C., Gasser T., Brown Jr R.H., Landers J.E., Robberecht W., Ludolph A.C., Ophoff R.A., Veldink J.H. and van den Berg L.H. (2010) A large genome scan for rare CNVs in amyotrophic lateral sclerosis. Human Molecular Genetics, doi: 10.1093/hmg/ddq323.
• Bento-Abreu A., Van Damme P., Van Den Bosch L. and Robberecht W. (2010) The neurobiology of amyotrophic lateral sclerosis. European Journal of Neuroscience 31: 2247-65.
• Irobi J., Almeida-Souza L., Asselbergh B., De Winter V., Goethals S., Dierick I., Krishnan J., Timmermans J.P., Robberecht W., De Jonghe P., Van Den Bosch L., Janssens S. and Timmerman V. (2010) Mutant HSPB8 causes motor neuron-specific neurite degeneration. Human Molecular Genetics 19: 3254-65.
• Bogaert E., Goris A., Van Damme P., Geelen V., Lemmens R., van Es M.A., van den Berg L.H., Kristel Sleegers K., Verpoorten N., Timmerman V., De Jonghe P., Van Broeckhoven C., Traynor B.J., Landers, J.E., Brown, Jr. R.H., Glass J.D., Al-Chalabi A., Shaw C.E., Birve A., Andersen P.M., Slowik A., Tomik B., Melki J., Robberecht W. and Van Den Bosch L. (2010) Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis. Neurobiology of Aging, doi:10.1016/j.neurobiolaging.2010.03.007.
• Taes I., Goris A., Lemmens R., van Es M.A., van den Berg L.H., Chio A., Traynor B.J., Birve A., Andersen P., Slowik A., Tomik B., Brown Jr. R.H., Shaw C.E., Al-Chalabi A., Boonen S., Van Den Bosch L., Dubois B., Van Damme P., Robberecht W. (2010) Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse. Neurology 74(21): 1687-93.
• Lemmens R., Moore M.J., Al-Chalabi A., Brown Jr. R.H. and Robberecht W. (2010) RNA metabolism and the pathogenesis of motor neuron diseases. Trends in Neurosciences 33(5): 249-58.
• Brockington A., Heath P.R., Holden H., Kasher P., Bender F.L., Claes F., Lambrechts D., Sendtner M., Carmeliet P., Shaw P.J. (2010) Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis. BMC Genomics 11: 203. 

Frontotemporal degeneration

• Van Langenhove T., van der Zee J., Sleegers K., Engelborhgs S., Vandenberghe R., Gijselinck I., Van den Broeck M., Mattheijssens M., Peeters K., De Deyn P.P., Cruts M., Van Broeckhoven C. (2010) Genetic contribution of FUS to frontotemporal lobar degeneration. Neurology 74(2010): 366-371.
• Nelissen N., Pazzaglia M., Vandenbulcke M., Sunaert S., Fannes K., Dupont P., Aglioti S.M., Vandenberghe R. (2010) Gesture discrimination in primary progressive aphasia: the intersection between gesture and language processing pathways. Journal of Neurosciences 30: 6334-6341. 

Other Disorders

• De Strooper B. Cancer and neurodegeneration meet. EMBO Molecular Medicine 2(7): 245-6.
• Khong T.M., Habets R.L.P., Slabbaert J., Verstreken P. (2010) Wiscott-Aldrich Syndrome Protein is activated by PI(4,5)P₂ to restrict neuromuscular junction growth in a pathway parallel to BMP signaling. Proceedings of the National Academy of Sciences 107: 17379-17384.
• Quaegebeur A., Carmeliet P. (2010) Oxygen sensing: a common crossroad in cancer and neurodegeneration. Current Topics in Microbiology and Immunology 345: 71-103.
• Goris A., Boonen S., D'hooghe M.B., Dubois B. (2010) Replication of KIF21B as a susceptibility locus for multiple sclerosis. Journal of Medical Genetics 47(11): 775-6.
• International Multiple Sclerosis Genetics Consortium (IMSGC), Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J. (2010) Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics Jun;42(6):4.

Basic Neurosciences

• Glyvuk N., Tsytsyura Y., Geumann C., D'Hooge R., Hüve J., Kratzke M., Baltes J., Böning D., Klingauf J., Schu P. (2010) AP-1/σ1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO Journal 29: 1318-1330.
• Woolley D.G., Vermaercke B., Op de Beeck H., Wagemans J., Gantois I., D'Hooge R., Swinnen S.P., Wenderoth N. (2010) Sex differences in human virtual water maze performance: Novel measures reveal the relative contribution of directional responding and spatial knowledge. Behavioural Brain Research 208: 408-414.
• Coremans V., Ahmed T., Balschun D., D’Hooge R., De Vriese A., Cremer J., Antonucci F., Moons M., Baekelandt V., Reumers V., Cremer H., Eisch A., Lagace D., Janssens T., Bozzi Y., Caleo M., Conway E. (2010) Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neuroscience 11: 2.
• Balschun D., Moechars D., Callaerts-Vegh Z., Vermaercke B., Van Acker N., Andries L., D’Hooge R. (2010) Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cerebral Cortex 20: 684-693.
• Verhoef B.-E., Vogels R., Janssen, P. (2010) The contribution of inferior temporal and posterior parietal activity to three-dimensional shape perception. Current Biology 20: 909-913.
• Quaegebeur A., Segura I., Carmeliet P. (2010) Pericytes: blood-brain barrier safeguards against neurodegeneration? Neuron 68(3): 321-3.
• Fiesel F.C., Voigt A., Weber S.S., Van den Haute C., Waldenmaier A., Görner K., Walter M., Anderson M.L., Kern J.V., Rasse T.M., Schmidt T., Springer W, Kirchner R., Bonin M., Neumann M., Baekelandt V., Alunni-Fabbroni M., Schulz J.B., Kahle P.J. (2010) Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO Journal 29(1): 209-21.
• Verhoef B.E., Vogels R., Janssen P.  (2010) The contribution of inferior temporal and posterior parietal activity to three-dimensional shape perception. Current Biology 20: 909-913.
• Wang J.,Van Damme P.,Cruchaga C., Gitcho M.A., Manuel Vidal J., Seijo-Martínez M., Wang L., Wu J.Y., Robberecht W., Goate A. (2010) Pathogenic cysteine mutations affect progranulin function and production of mature granulins. Journal of Neurochemistry 112(5): 1305-15.