SCIL > Research program section > Musculoskeletal Program
Musculoskeletal Program
MSC (marrow stromal cells, mesenchymal stem cells) are multipotent cells found primarily in bone marrow. They have long been known to be capable of osteogenic, adipogenic differentiation. Recently, it has been suggested that the local stem cell niche can influence the lineage commitment of MSC. For instance, periosteum derived MSC, evaluated extensively by the group of Dr. F. LUYTEN, appear best suited for osteogenesis, whereas myogenic and even cardiomyogenic potential has been shown from Mesangioblasts (Mabs) found in muscle and in heart, as described by the group of Dr. M. SAMPAOLESI.
In this joined program the influence of place of origin (bone, muscle, heart) on the ability of such cells to be used for repair of bone, cartilage and muscles will be studied, as well as the effect of cytokines, biomaterials and other factors on stem cell differentiation and applications in the musculoskeletal system.
