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SCIL > Research program section > Neurobiology Program

Neurobiology Program

In this program, investigators

1. under the direction of Dr. W. ROBBERECHT are generating iPSC from patients with fronto-temporal dementia (caused by a genetic abnormality in the progranulin gene) and ALS to study the role of the gene defects in human neurodegeneration

1. under the direction of Dr. V. BAEKELANDT are studying the role of endogenous neural stem cells in neurodegeneration such as Parkinson.

Lab members

Robberecht lab

Publications

W Robberecht Lab

1. Peer reviewed journals

++2009++

Brugman F, Veldink JH, Franssen H, de Visser M, de Jong JM, Faber CG, Kremer BH, Schelhaas HJ, van Doorn PA, Verschuuren JJ, Bruyn RP, Kuks JB, Robberecht W, Wokke JH, van den Berg LH. Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromes. Arch Neurol. 2009; 66:509-14.
IF 5.783

C Sage, W Van Hecke, R Peeters, J Sijbers, W Robberecht, Parizel P, Marchal G, Leemans A, Sunaert S. Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Human Brain Mapping, accepted for publications
IF 6.277

Philip Van Damme, Philippe Demaerel, Werner Spileers, and Wim Robberecht. Autosomal Resessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS). Neurology 2009; accepted for publication
IF 5,690

Van Es MA, Van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, Van Der Kooi AJ, De Visser M, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, Van Den Berg LH. Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009; Epub ahead of print
IF 0.843

Bogaert E, Van Damme P, Poesen K, Dhondt J, Hersmus N, Kiraly D, Scheveneels W, Robberecht W, Van Den Bosch L. VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. Neurobiol Aging. 2009; Epub ahead of print
IF 5.607

Baets J, Dierick I, Groote CC, Ende J, Martin JJ, Geens K, Robberecht W, Nelis E, Timmerman V, Jonghe PD. Peripheral neuropathy and 46XY gonadal dysgenesis: a heterogeneous entity. Neuromuscul Disord. 2009;19:172-5. Epub
IF 2.667.

 

Chabwine JN, Talavera K, Verbert L, Eggermont J, Vanderwinden JM, De Smedt H, Van Den Bosch L, Robberecht W, Callewaert G. Differential contribution of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons. FASEB J. 2009 ;23:1168-76
IF 6.963

Kristel Sleegers, Philip Van Damme, Sebastiaan Engelborghs, Rik Vandenberghe, Nathalie Brouwers, Ilse Gijselinck, Julie van der Zee, Karin Peeters, Mie Mattheijssens, Marc Cruts, Peter P De Deyn, Wim Robberecht and Christine Van Broeckhoven. Serum progranulin is a biomarker for PGRN-related ubiquitin-immunoreactive frontotemporal lobar degeneration. Annals of Neurology 2009; accepted for publication,
IF 8,813

Lemmens R, Race V, Hersmus N, Matthijs G, Van Den Bosch L, Van Damme P, Dubois B, Boonen S, Goris A, Robberecht W. TDP-43 M311V mutation in familial amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2009; 80(3):354-5
IF 3.857

L Simpson*, R Lemmens* K Miskiewicz, WJ Broom, VK Hansen, PWJ van Vught, JE Landers, P Sapp, L Van Den Bosch, J Knight, BM Neale, MR Turner, JH Veldink, RA Ophoff, VB Tripathi, A Beleza, MN  Shah, P Proitsi, A Van Hoecke, P Carmeliet, HR Horvitz, PN Leigh, CE Shaw, LH van den Berg PC Sham, JF Powell, P Verstreken, RH Brown Jr, W Robberecht,  A Al-Chalabi. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet 2009; 18(3):472-81.
IF 8.099

 

++2008++

Geneviève Gowing*, Thomas Philips*, Bart Van Wijmeersch, Jean-Nicolas Audet, Maarten Dewil, Ludo Van Den Bosch, An Billiau, Wim Robberecht, and Jean-Pierre Julien. Ablation of proliferating microglia does not affect motor neuron degeneration in ALS caused by mutant SOD1. J Neurosci 2008; 28:10234-44.
IF 7.490

Diether Lambrechts, Koen Poesen, Philip Van Damme, Joke Dhondt, Eve Peerard, An Verheyen, Florian Bender, Katie Van Geyte, Elke Bogaert, Bart Claes, Manu Beeren, Line Heylen, Marc Tjwa, Masabumi Shibuya, Rudi Dooghe, Ludo Van Den Bosch, Theo Meert, Michael Sendtner, Wim Robberecht, Rony Nuydens, Peter Carmeliet. Novel Role for VEGF-Receptor-1 and its Ligand VEGF-B in Motor Neuron Degeneration and sensory neuropathy. J Neurosci 2008; 28:10451-9.
IF 7.490

J Krishnan, K  Vannuvel, M  Andries, E  Waelkens, W Robberecht, L Van Den Bosch. Overexpression of Hsp27 does not influence disease in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis. J Neurochem 2008; 106:2170-83.
IF 4.451

Lambrechts D, Poesen K, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Van Vught PW, Khan S, Marklund S, Brockington A, Van Marion I, Anneser J, Shaw C, Ludolph A, Leigh PN, Comi G, Gasser T, Shaw, PJ, Marrison K, Anderson P, van den Berg, LH, Thijs V, Siddique T, Robberecht W, Carmeliet P. Meta-analysis of VEGF variations in ALS: increased susceptibility in male carriers of the -2578AA genotype. J. Med Genet. 2008 in press
IF 5.087

P Van Damme, A Van Hoecke, D Lambrechts, Peter Vanacker, E Bogaert, J van Swieten, P Carmeliet, L Van Den Bosch and W Robberecht. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biology, 2008; 181: 37-41
IF 10,152

Ines Dierick, Jonathan Baets, Joy Irobi, An Jacobs, Els De Vriendt, Tine Deconinck, Luciano Merlini, Peter Van den Bergh, Vedrana Milic Rasic, Wim Robberecht, Dirk Fischer, Raul Juntas Morales, Zoran Mitrovic, Pavel Seeman, Radim Mazanec, Andrzej Kochanski, Albena Jordanova, Michaela Auer-Grumbach, A.T.J.M. Helderman-van den Enden, John H.J. Wokke, Eva Nelis, Peter De Jonghe and Vincent Timmerman. Relative contribution of mutations in genes for autosomal dominant distal hereditary motor neuropathies: a genotype – phenotype correlation study. Brain 2008; 131:1217-27.
IF 7,617

Van Den Bosch L, Robberecht W. Crosstalk between astrocytes and motor neurons: What is the message? Experimental Neurology 2008; 211:1-6
IF 4,156

Leigh PN, Meininger V, Bensimon G, Cudkowicz M, Robberecht W.Minocycline for patients with ALS. Lancet Neurol. 200; 2:119-20
IF 9,479

MA van Es, PW van Vught, H Blauw, L  Franke,  L Van Den Bosch, SW de Jong, V de Jong, F Baas, R van ’t Slot, R Lemmens, JH Schelhaas, A Birve, Kr Sleegers, C van Broeckhoven, JC Schymick, BJ Traynor, JJH Wokke, C Wijmenga, W Robberecht, PM Andersen, JH Veldink, RA Ophoff, LH. van den Berg. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis; Nature Genetics, 2008; 40: 29-31
IF 24,176

K. Sleegers, N. Brouwers, S. Maurer-Stroh, M.A. van Es, P. Van Damme, P.W.J van Vught, J. van der Zee, S. Serneels, T. De Pooter, M. Van den Broeck, M. Cruts, J. Schymkowitz, P. DeJonghe, F. Rousseau, L.H. van den Berg, W. Robberecht, C. Van Broeckhoven. Progranulingenetic variability contributes to amyotrophic lateral sclerosis. Neurology, 2008; 71:253-9.
IF 5,690

++2007++

I Gijselinck, K Sleegers, S Engelborghs, W Robberecht, JJ Martin, R Vandenberghe, R Sciot, B Dermaut, D Goossens, J van der Zee, T De Pooter, J Del-Favero, P Santens, P De Jonghe, PP. De Deyn, C Van Broeckhoven, M Cruts. Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS. Neurobiology of Aging, accepted for publication, 2007
IF 5,599

MA van Es, PWJ van Vught, HM Blauw, L  Franke,  L Van Den Bosch, SW de Jong, V de Jong, F Baas, R van ’t Slot, R Lemmens, H J Schelhaas, A Birve, Kl Sleegers, C van Broeckhoven, JJH Wokke, C Wijmenga, W Robberecht, PM Andersen, JH Veldink, RA Ophoff,  L H. van den Berg. Genome-wide association study of sporadic amyotrophic lateral sclerosis identifies ITPR2 as a susceptibility gene. The Lancet Neurology, 2007; 6: 869-77
IF 9.479

P Van Damme*, E Bogaert*, M Dewil, N Hersmus, D Kiraly, W Scheveneels, I Bockx, D Braeken, N Verpoorten, K Verhoeven, V Timmerman, P Herijgers, G Callewaert, P Carmeliet, L Van Den Bosch, W Robberecht. Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc Natl Acad Sci USA 2007; 104: 14825-30
IF 9.643

R Lemmens*, A Van Hoecke*, N Hersmus, V Geelen, V Thijs, L Van Den Bosch, P Carmeliet, W Robberecht. Mutant SOD1-induced motor axonopathy in the zebrafish as a novel model to identify therapeutic targets and genetic modifiers in ALS. Hum Mol Genetics 2007; 16:2359-65
IF 8.099

D Lambrechts, W Robberecht, P Carmeliet. Understanding ALS by identifying common principles with other motoneuron degeneration disorders. Trends in Neurosciences 2007; 30: 536-44
IF 13.494

I Dierick, J Irobi, S Janssens, J Theuns, R Lemmens , A Jacobs, E Corsmit, N Hersmus, L Van Den Bosch, W Robberecht, P De Jonghe, C Van Broeckhoven, V Timmerman. Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response. Hum Mut 2007; 28: 830
IF 7,293

M Dewil, D Kiraly, R Sciot, PJ Shaw, PG Ince, W Robberecht, L Van Den Bosch. VEGF rescues the loss of activated Akt preceding motoneuron degeneration in ALS. J Neuropathol Appl Neurobiol, 2007; 33: 499-509
IF 3.266

Schymick J, Yang Y, Andersen PM, Vonsatel JPl, Greenway M, Momeni P, Elder J, Chiò A, Restagno G,  Robberecht  W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, Hutton M, Gass J, Cannon A, Rademakers R, Singleton A, Hardiman O, Rothstein J, Hardy J, Traynor BJ. Progranulin mutations are not associated with sporadic and familial ALS. J Neurol Neurosurg Psych 2007; 78:754-6.
IF 3,122

Dewil M,de la Cruz VF,Van Den Bosch L, Robberecht W. Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death. Neurobiology of Disease 2007; 26:332-41.
IF 4.048

Sage C, Peeters R, Görner A, Robberecht W, Sunaert S. Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis, NeuroImage 2007; 34:486-499
IF 5.288

Andries M, Van Damme P, Robberecht W, Van Den Bosch L. Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends life span of a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2007; 25: 8-16.
IF 4.048

Grosskreutz J, Haastert K, Dewil M, Van Damme P, Callewaert G, Robberecht W, Dengler R and Van Den Bosch L. Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons. Cell Calcium, 2007: 42:59-69
IF 4,939

 

++2006++

Goeleven A, Robberecht W, Sonies B, Carbonez A, Dejaeger E. Manofluorographic evaluation of swallowing in amyotrophic lateral sclerosis and its relationship with clinical evaluation of swallowing. Amyotroph Lateral Scler. 2006; 7: 235-240.
IF 0.843

Verhoeven K, Claeys KG, Züchner S, SchröderJM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec , Saifi GS, Sziget K, Mancias P, Butler IJ, Kochanski, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N,  Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev Y, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen H. –J,Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V.  MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain 2006: 129: 2093-2102
IF 8.201

L.Van Den Bosch, P.Van Damme, E. Bogaert and W. Robberecht. The Role of Excitotoxicity in the Pathogenesis of Amyotrophic Lateral Sclerosis. Biochim Biophys Acta 2006: 1762: 1068-1082
IF 3.046

Krishnan J, Lemmens R, Robberecht W, Van Den Bosch L. Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death. Exp Neurol 2006: 200: 301-310
IF 3.369

Bogaert E, Van Damme P, Van Den Bosch L, Robberecht W. VEGF in amyotrophic lateral sclerosis and other neurodegeneration. Muscle and Nerve: 2006: 34: 391-405
IF 2.432

Regal L, Vanopdenbosch L, Tilkin P, Thijs V, Sciot R, Van Den Bosch L, Robberecht W. The G93C mutation in superoxide dismutase 1: clinicopathological phenotype and prognosis. Arch Neurol 2006: 63: 262-267
IF 4.684

Meininger V, Asselain B, Guillet P, Leigh PN, Ludolph A, Lacomblez L, Robberecht W. Pentoxifylline in amyotrophic lateral sclerosis: a double blind, randomized, multicenter, placebo controlled trial. Lessons for future trials. Neurology, 2006; 66: 88-92
IF 5.678

Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet. 2006, 38:197-202
IF 26.711

++2005++
Van Damme P, Dewil M, Robberecht W, Van Den Bosch L. Excitotoxicity and amyotrophic lateral sclerosis. Neurodegenerative Diseases 2005; 2: 147-159
IF: not yet available

Verpoorten N, Verhoeven K, Weckx S, Jacobs A, Serneels S, Del Favero J, Ceuterick C, Van Bockstaele DR, Berneman ZN, Van Den Bosch L, Robberecht W, Nobbio L, Schenone A, Dessaud E, Delapeyriere O, Huylebroeck D, Zwijsen A, De Jonghe P, Timmerman V. Synaptopodin and 4 novel genes identified in primary sensory neurons.
Mol Cell Neurosci. 2005; 30:316-25.
IF: 3.789

Petri S., Schmalbach S., Grosskreutz J., Krampfl K., Dengler R., Van Den Bosch L., Robberecht W., Bufler J. The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice.  J Neurol Sci, 2005; 238:25-30.
IF 2,366

Van Damme P, Braeken D, Callewaert G, Robberecht W, Van Den Bosch L. GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis. J Neuropath Exp Neurol 2005;64:605-12
IF 5.005

Van Assche G, Van Ranst M, Sciot R., Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K,  Robberecht W, Rutgeerts P. Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn’s Disease. New Engl J Med 2005; 353:362-8
IF 34.833

Dewil M, Schurmans C, Starckx S, Opdenakker G, Van Den Bosch L, Robberecht W.  Role of Gelatinase B/Matrix Metalloprotease-9 in a Mouse model for ALS. Neuroreport, 2005; 16:321-4.
IF 2,503

Laing NG, Dye D, Ceuterick DeGroote C, Liyanage K, Dubois B, Robberecht W, Sciot R, Martin J-J,Goebel HH. Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases Neurology, 2005; 64: 527-529
IF 5.678

W Robberecht, B Jubelt. Reverse Transcriptase takes ALS back to viruses. Neurology, 2005; 64: 410-411
IF 5.678

Erik Storkebaum, Diether Lambrechts, Hideyasu Oh, Mieke Dewerchin, Kristel Vermeulen, Philip Van Damme, WingYan Man, Maria Demol, Sabine Wyns, David Manka, Ludo Vanopdenbosch, Nico Mertens, Wim Robberecht, Désiré Collen, Edward M. Conway, Lieve Moons and Peter Carmeliet. Treatment of an aggressive form of motoneuron degeneration with intracerebroventricular delivery of recombinant VEGF in ALS animal model. Nature Neuroscience 2005; 8: 85-92.
IF15,141

 

++ 2004 ++
Joy Irobi, Katrien Van Impe, Pavel Seeman, Albena Jordanova, Ines Dierick, Nathalie Verpoorten, Andrej Michalik, Els De Vriendt, An Jacobs, Veerle Van Gerwen, Krist’l Vennekens, Radim Mazanec, Ivailo Tournev, David Hilton-Jones, Kevin Talbot, Ivo Kremensky, Ludo Van Den Bosch, Wim Robberecht, Joel Vandekerckhove, Christine Van Broeckhoven, Jan Gettemans, Peter De Jonghe, Vincent Timmerman. Hot spot residue in small heat shock protein 22 causes distal motor neuropathy. Nature Genetics, 2004; 36: 597-601.
IF 26.711

Oleg Evgrafov, Irena Mersiyanova, Joy Irobi, Ludo Van Den Bosch, Ines Dierick, Conrad L. Leung, Olga Schagina, Nathalie Verpoorten, Katrien Van Impe, Valeriy Fedotov, Elena Dadali, Michaela Auer-Grumbach, Christian Windpassinger, Klaus Wagner, Zoran Mitrovic, David Hilton-Jones , Kevin
Talbot , Jean-Jacques Martin, Svetlana Tverskaya, Alexander Polyakov, Ronald K. H. Liem, Jan Gettemans, Wim Robberecht, Peter De Jonghe, Vincent Timmerman. Mutations in small heat shock protein 27 (HSPB1) cause axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Nature Genetics, 2004; 36: 602-606
IF 26.711

Thijs VN, Somford DM, Bammer R, Robberecht W, Moseley ME, Albers GW.Influence of arterial input function on hypoperfusion volumes measured with perfusion-weighted imaging. Stroke. 2004 ;35:94-98
IF 5.233

L Van Den Bosch, E Storkebaum, V Vleminickx, L Moons, L Vanopdenbosch, W Scheveneels, P Carmeliet, W Robberecht. Vascular Endothelial Growth Factor (VEGF) and motoneuron degeneration. Neurobiol Dis 2004; 17, 21-28
IF 5.153

Joelle N. Chabwin, Philip Van Damme, Jan Eggermont, Humbert De Smedt, Ludwig Missiaen, Ludo Van Den Bosch, Jan B. Parys, Wim Robberecht and Geert Callewaert. Long-lasting changes in GABA responsiveness in cultured neurons. Neurosci Lett 2004: 365: 69-72.
IF 2.100

Meininger V, Bensimon G, Bradley WG, Brooks B, Douillet P, Lacomblez L, Leigh PN, Robberecht W. Efficacy and Safety of Xaliproden in Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2004; 5: 107-117.
IF 0.848

++ 2003 ++
Demaerel P, Sciot R, Robberecht W, Dom R, Vandermeulen D, Maes F, Wilms G. Accuracy of diffusion-weighted MR imaging in teh diagnosis of sporadic Creutzfeldt-Jakob disease. J Neurol 2003; 250: 222-225.
IF 2.778

V Thijs, W Robberecht, R De Vos, R Sciot. Coexistence of CADASIL and Alzheimer’s disease. J Neurol Neurosurg Psych (2003), 74: 790-792.
IF 3.035

Van Damme P, Leyssen M, Callewaert G, Robberecht W, Van Den Bosch L. The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of Amyotrophic Lateral Sclerosis, Neurosci Lett 2003; 353: 81-84.
IF 2.100

Van Damme P, Callewaert G, Eggermont J, Robberecht W, Van Den Bosch L. Chloride influx aggravates calcium-dependent AMPA receptor-mediated motoneuron death. J Neurosci 2003; 23: 4942-4950.
IF 8.306

Cassiman D, Thomeer G, Robberecht W. Hypersensitivity pneumonitis possibly caused by
riluzole therapy in ALS. Neurology 2003; 61:1150-1151.
IF,5.678

Derave W, Van Den Bosch L, Lemmens G, Eijnde BO, Robberecht W, Hespel P. Skeletal Muscle Properties in a Transgenic Mouse Model for Amyotrophic Lateral Sclerosis: Effects of Creatine Treatment. Neurobiol Dis (2003); 13: 264-272.
IF 5.153

Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Singh Pall H, Prats H, Vermeire S, Rutgeerts P, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM and Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans, and protects motoneurons against ischemic death. Nature Genetics 2003; 34: 383-394.
 IF 26.711

De Bruecker Y, Demaerel P, Wilms G, Sciot R, Ballaux F, Robberecht W. A case of hemiparesis associated with cranial nerve lesions due to intravascular lymphomatosis. Eur Radiol 2003; 13: 1753-1755.
IF 1.969

++ 2002 ++
Van Den Bosch L, Schwaller B, Vleminckx V, Meijers B, Stork S, Ruehlicke T, Van Houtte E, Klaassen H, Celio MR, Missiaen L, Robberecht W (corresponding author), Berchtold M. Protective effect of parvalbumin on excitotoxic motor neuron death. Exp Neurol 2002;174:150-61.
IF 3.676

Merlevede K, Vermander D, Theys P, Legius E, Robberecht W. Cardiac involvement and CTG expansion in Myotonic Dystrophy. J Neurol, 2002; 249:693-698
IF 2.778

Van Den Bosch L, Van Damme P, Vleminckx V, Van Houtte E, Lemmens G, Missiaen L, Callewaert G, Robberecht W. An a-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death by a mechanism different from calpain inhibition. Neuropharmacology 2002; 42: 706-713.
IF 3.801

Van Den Bosch L, Tilkin P, Lemmens G, Robberecht W. Minocycline delays disease and mortality in a transgenic model of familial ALS. Neuroreport 2002; 13:1067-1070.
IF 2.503

Van Damme P, Van Den Bosch L, Van Houtte E, Eggermont J, Callewaert G, Robberecht W. Sodium entry through AMPA receptors results in voltage-gated potassium channel blockade in cultured rat spinal cord motor neurons. J Neurophysiology 2002; 88: 965-972.
IF 3.876

Jonsson PA, Bäckstrand Å, Andersen PM, Jakobsson J, Parton M, Shaw CE, Swingler R, Shaw PJ, Robberecht W, Ludolph A, Siddique T, Skvortsova V, Marklund SL. CuZn-superoxide dismutase in D90A heterozygotes from recessive and dominant ALS pedigrees. Neurobiology of Disease 2002; 10: 327-333.
IF 5.153

Van Damme P, Van Den Bosch L, Van Houtte E, Callewaert G, Robberecht W. GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity. J Neurophysiol 2002; 88:1279-1287.
IF 3.876

Vleminckx V, Van Damme P, Goffin K, Delye H, Van Den Bosch L, Robberecht W. Nuclear and cytoplasmic upregulation of HSP27 in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2002; 61:968-974
IF 5.005

V Baekelandt Lab