Pierre Vanderhaeghen

Onderzoeksgroep Moleculaire Neurobiologie (VIB-KU Leuven)

ON5 Herestraat 49 - bus 602

3000 Leuven

KU Leuven kaart

Curriculum Vitae

 

 

Recente projecten

Volledige projectlijst in het onderzoeksportaal

Recente publicaties

  • launch Casimir, P., Vanderhaeghen, P. (sup.), Gall, D. (sup.), Iwata, R. (cosup.) (2024). Mitochondria Metabolism Sets the Species-Specific Tempo of Neuronal Development.
  • launch Atsumi, Y., Iwata, R., Kimura, H., Vanderhaeghen, P., Yamamoto, N., Sugo, N. with Yamamoto, N. (corresp. author), Sugo, N. (corresp. author) (2024). Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons. CELL REPORTS, 43 (1), Art.No. ARTN 113576. doi: 10.1016/j.celrep.2023.113576 openaccessvia repository
  • launch Libe-Philippot, B., Lejeune, A., Wierda, K., Louros, N., Erkol, E., Vlaeminck, I., Beckers, S., Gaspariunaite, V., Bilheu, A., Konstantoulea, K., Nyitrai, H., Vleeschouwer, M.D., Vennekens, K.M., Vidal, N., Bird, T.W., Soto, D.C., Jaspers, T., Dewilde, M., Dennis, M.Y., Rousseau, F., Comoletti, D., Schymkowitz, J., Theys, T., de Wit, J., Vanderhaeghen, P. with de Wit, J. (corresp. author), Vanderhaeghen, P. (corresp. author) (2023). LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons. CELL, 186 (26). doi: 10.1016/j.cell.2023.11.028 openaccessvia repository
  • launch Vanderhaeghen, P., Polleux, F. with Vanderhaeghen, P. (corresp. author), Polleux, F. (corresp. author) (2023). Developmental mechanisms underlying the evolution of human cortical circuits. NATURE REVIEWS NEUROSCIENCE, 24 (4), 213-232. doi: 10.1038/s41583-023-00675-z
  • launch Pilaz, L-J., Liu, J., Joshi, K., Tsunekawa, Y., Musso, C.M., D'Arcy, B.R., Suzuki, I.K., Alsina, F.C., Pratiksha, K.C., Sethi, S., Vanderhaeghen, P., Polleux, F., Silver, D.L. with Silver, D.L. (corresp. author) (2023). Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. NEURON, 111 (6), 839-+. doi: 10.1016/j.neuron.2023.02.023
  • launch Iwata, R., Casimir, P., Erkol, E., Boubakar, L., Planque, M., Lopez, I.M G., Ditkowska, M., Gaspariunaite, V., Beckers, S., Remans, D., Vints, K., Vandekeere, A., Poovathingal, S., Bird, M., Vlaeminck, I., Creemers, E., Wierda, K., Corthout, N., Vermeersch, P., Carpentier, S., Davie, K., Mazzone, M., V. Gounko, N., Aerts, S., Ghesquiere, B., Fendt, S-M., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2023). Mitochondria metabolism sets the species-specific tempo of neuronal development. SCIENCE, 379 (6632), Art.No. ARTN eabn4705, 553-+. doi: 10.1126/science.abn4705
  • launch Van Heurck, R., Bonnefont, J., Wojno, M., Suzuki, I.K., Velez-Bravo, F.D., Erkol, E., Nguyen, D.T., Herpoel, A., Bilheu, A., Beckers, S., Ledent, C., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2023). CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. NEURON, 111 (1), 65-+. doi: 10.1016/j.neuron.2022.10.018 openaccessvia repository
  • launch Vermaercke, B., Bonin, V., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2022). Studying human neural function in vivo at the cellular level: Chasing chimeras? CELL, 185 (26), 4869-4872. doi: 10.1016/j.cell.2022.11.020 openaccessvia repository
  • launch Iwata, R., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2021). Regulatory roles of mitochondria and metabolism in neurogenesis. CURRENT OPINION IN NEUROBIOLOGY, 69, 231-240. doi: 10.1016/j.conb.2021.05.003 openaccessvia repository
  • launch Sonderby, I.E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G.B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N.J., Bernard, M., Blackburn, N.B., Blangero, J., Boomsma, D.I., Brodaty, H., Brouwer, R.M., Buelow, R., Boen, R., Cahn, W., Calhoun, V.D., Caspers, S., Ching, C.R K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J.E., Dale, A.M., Dalvie, S., Dazzan, P., de Geus, E.J C., de Zubicaray, G.I., de Zwarte, S.M C., Desrivieres, S., Doherty, J.L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S.E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Ge, T., Glahn, D.C., Grabe, H.J., Groenewold, N.A., Gustafsson, O., Haavik, J., Haberg, A.K., Hall, J., Hashimoto, R., Hehir-Kwa, J.Y., Hibar, D.P., Hillegers, M.H J., Hoffmann, P., Holleran, L., Holmes, A.J., Homuth, G., Hottenga, J-J., Hulshoff Pol, H.E., Ikeda, M., Jahanshad, N., Jockwitz, C., Johansson, S., Joensson, E.G., Jorgensen, N.R., Kikuchi, M., Knowles, E.E M., Kumar, K., Le Hellard, S., Leu, C., Linden, D.E J., Liu, J., Lundervold, A., Lundervold, A.J., Maillard, A.M., Martin, N.G., Martin-Brevet, S., Mather, K.A., Mathias, S.R., McMahon, K.L., McRae, A.F., Medland, S.E., Meyer-Lindenberg, A., Moberget, T., Modenato, C., Sanchez, J.M., Morris, D.W., Muehleisen, T.W., Murray, R.M., Nielsen, J., Nordvik, J.E., Nyberg, L., Loohuis, L.M O., Ophoff, R.A., Owen, M.J., Paus, T., Pausova, Z., Peralta, J.M., Pike, G.B., Prieto, C., Quinlan, E.B., Reinbold, C.S., Marques, T.R., Rucker, J.J H., Sachdev, P.S., Sando, S.B., Schofield, P.R., Schork, A.J., Schumann, G., Shin, J., Shumskaya, E., Silva, A.I., Sisodiya, S.M., Steen, V.M., Stein, D.J., Strike, L.T., Suzuki, I.K., Tamnes, C.K., Teumer, A., Thalamuthu, A., Tordesillas-Gutierrez, D., Uhlmann, A., Ulfarsson, M.O., van 't Ent, D., van den Bree, M.B M., Vanderhaeghen, P., Vassos, E., Wen, W., Wittfeld, K., Wright, M.J., Agartz, I., Djurovic, S., Westlye, L.T., Stefansson, H., Stefansson, K., Jacquemont, S., Thompson, P.M., Andreassen, O.A. with Sonderby, I.E. (corresp. author) (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. TRANSLATIONAL PSYCHIATRY, 11 (1), Art.No. ARTN 182. doi: 10.1038/s41398-021-01213-0 openaccessvia repository

Recente projecten

Volledige projectlijst
in het onderzoeksportaal

Recente publicaties

  • launch Casimir, P., Vanderhaeghen, P. (sup.), Gall, D. (sup.), Iwata, R. (cosup.) (2024). Mitochondria Metabolism Sets the Species-Specific Tempo of Neuronal Development.
  • launch Atsumi, Y., Iwata, R., Kimura, H., Vanderhaeghen, P., Yamamoto, N., Sugo, N. with Yamamoto, N. (corresp. author), Sugo, N. (corresp. author) (2024). Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons. CELL REPORTS, 43 (1), Art.No. ARTN 113576. doi: 10.1016/j.celrep.2023.113576 openaccessvia repository
  • launch Libe-Philippot, B., Lejeune, A., Wierda, K., Louros, N., Erkol, E., Vlaeminck, I., Beckers, S., Gaspariunaite, V., Bilheu, A., Konstantoulea, K., Nyitrai, H., Vleeschouwer, M.D., Vennekens, K.M., Vidal, N., Bird, T.W., Soto, D.C., Jaspers, T., Dewilde, M., Dennis, M.Y., Rousseau, F., Comoletti, D., Schymkowitz, J., Theys, T., de Wit, J., Vanderhaeghen, P. with de Wit, J. (corresp. author), Vanderhaeghen, P. (corresp. author) (2023). LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons. CELL, 186 (26). doi: 10.1016/j.cell.2023.11.028 openaccessvia repository
  • launch Vanderhaeghen, P., Polleux, F. with Vanderhaeghen, P. (corresp. author), Polleux, F. (corresp. author) (2023). Developmental mechanisms underlying the evolution of human cortical circuits. NATURE REVIEWS NEUROSCIENCE, 24 (4), 213-232. doi: 10.1038/s41583-023-00675-z
  • launch Pilaz, L-J., Liu, J., Joshi, K., Tsunekawa, Y., Musso, C.M., D'Arcy, B.R., Suzuki, I.K., Alsina, F.C., Pratiksha, K.C., Sethi, S., Vanderhaeghen, P., Polleux, F., Silver, D.L. with Silver, D.L. (corresp. author) (2023). Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. NEURON, 111 (6), 839-+. doi: 10.1016/j.neuron.2023.02.023
  • launch Iwata, R., Casimir, P., Erkol, E., Boubakar, L., Planque, M., Lopez, I.M G., Ditkowska, M., Gaspariunaite, V., Beckers, S., Remans, D., Vints, K., Vandekeere, A., Poovathingal, S., Bird, M., Vlaeminck, I., Creemers, E., Wierda, K., Corthout, N., Vermeersch, P., Carpentier, S., Davie, K., Mazzone, M., V. Gounko, N., Aerts, S., Ghesquiere, B., Fendt, S-M., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2023). Mitochondria metabolism sets the species-specific tempo of neuronal development. SCIENCE, 379 (6632), Art.No. ARTN eabn4705, 553-+. doi: 10.1126/science.abn4705
  • launch Van Heurck, R., Bonnefont, J., Wojno, M., Suzuki, I.K., Velez-Bravo, F.D., Erkol, E., Nguyen, D.T., Herpoel, A., Bilheu, A., Beckers, S., Ledent, C., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2023). CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. NEURON, 111 (1), 65-+. doi: 10.1016/j.neuron.2022.10.018 openaccessvia repository
  • launch Vermaercke, B., Bonin, V., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2022). Studying human neural function in vivo at the cellular level: Chasing chimeras? CELL, 185 (26), 4869-4872. doi: 10.1016/j.cell.2022.11.020 openaccessvia repository
  • launch Iwata, R., Vanderhaeghen, P. with Vanderhaeghen, P. (corresp. author) (2021). Regulatory roles of mitochondria and metabolism in neurogenesis. CURRENT OPINION IN NEUROBIOLOGY, 69, 231-240. doi: 10.1016/j.conb.2021.05.003 openaccessvia repository
  • launch Sonderby, I.E., van der Meer, D., Moreau, C., Kaufmann, T., Walters, G.B., Ellegaard, M., Abdellaoui, A., Ames, D., Amunts, K., Andersson, M., Armstrong, N.J., Bernard, M., Blackburn, N.B., Blangero, J., Boomsma, D.I., Brodaty, H., Brouwer, R.M., Buelow, R., Boen, R., Cahn, W., Calhoun, V.D., Caspers, S., Ching, C.R K., Cichon, S., Ciufolini, S., Crespo-Facorro, B., Curran, J.E., Dale, A.M., Dalvie, S., Dazzan, P., de Geus, E.J C., de Zubicaray, G.I., de Zwarte, S.M C., Desrivieres, S., Doherty, J.L., Donohoe, G., Draganski, B., Ehrlich, S., Eising, E., Espeseth, T., Fejgin, K., Fisher, S.E., Fladby, T., Frei, O., Frouin, V., Fukunaga, M., Gareau, T., Ge, T., Glahn, D.C., Grabe, H.J., Groenewold, N.A., Gustafsson, O., Haavik, J., Haberg, A.K., Hall, J., Hashimoto, R., Hehir-Kwa, J.Y., Hibar, D.P., Hillegers, M.H J., Hoffmann, P., Holleran, L., Holmes, A.J., Homuth, G., Hottenga, J-J., Hulshoff Pol, H.E., Ikeda, M., Jahanshad, N., Jockwitz, C., Johansson, S., Joensson, E.G., Jorgensen, N.R., Kikuchi, M., Knowles, E.E M., Kumar, K., Le Hellard, S., Leu, C., Linden, D.E J., Liu, J., Lundervold, A., Lundervold, A.J., Maillard, A.M., Martin, N.G., Martin-Brevet, S., Mather, K.A., Mathias, S.R., McMahon, K.L., McRae, A.F., Medland, S.E., Meyer-Lindenberg, A., Moberget, T., Modenato, C., Sanchez, J.M., Morris, D.W., Muehleisen, T.W., Murray, R.M., Nielsen, J., Nordvik, J.E., Nyberg, L., Loohuis, L.M O., Ophoff, R.A., Owen, M.J., Paus, T., Pausova, Z., Peralta, J.M., Pike, G.B., Prieto, C., Quinlan, E.B., Reinbold, C.S., Marques, T.R., Rucker, J.J H., Sachdev, P.S., Sando, S.B., Schofield, P.R., Schork, A.J., Schumann, G., Shin, J., Shumskaya, E., Silva, A.I., Sisodiya, S.M., Steen, V.M., Stein, D.J., Strike, L.T., Suzuki, I.K., Tamnes, C.K., Teumer, A., Thalamuthu, A., Tordesillas-Gutierrez, D., Uhlmann, A., Ulfarsson, M.O., van 't Ent, D., van den Bree, M.B M., Vanderhaeghen, P., Vassos, E., Wen, W., Wittfeld, K., Wright, M.J., Agartz, I., Djurovic, S., Westlye, L.T., Stefansson, H., Stefansson, K., Jacquemont, S., Thompson, P.M., Andreassen, O.A. with Sonderby, I.E. (corresp. author) (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. TRANSLATIONAL PSYCHIATRY, 11 (1), Art.No. ARTN 182. doi: 10.1038/s41398-021-01213-0 openaccessvia repository