Publications
- A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.
Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, Ulens C.
PLoS Biol. 2011 Mar;9(3):e1001034. - Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.
Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C.
J Biol Chem. 2011 Feb 11;286(6):4420-8. - The use of acetylcholine binding protein in the search for novel α7-nicotinic receptor ligands. In silico docking, pharmacological screening and X-ray analysis.
Ulens C, Akdemir A, Jongejan A, van Elk R, Edink E, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D and de Esch IJP.
J. Med. Chem. 2009 Apr 23;52(8):2372-83. - AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ.
EMBO J. 2007 Aug 22;26(16):3858-67. - Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.
Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma TK.
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3615-20. - Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry.
Ulens C, Siegelbaum SA.
Neuron. 2003 Dec 4;40(5):959-70. - Functional heteromerization of HCN1 and HCN2 pacemaker channels.
Ulens C, Tytgat J.
J Biol Chem. 2001 Mar 2;276(9):6069-72.
